@article {5149,
	title = {A prospective study on bacterial and atypical etiology of acute exacerbation in chronic obstructive pulmonary disease.},
	journal = {Future Microbiol},
	volume = {9},
	year = {2014},
	month = {2014},
	pages = {1251-60},
	abstract = {AIM: The bacterial and atypical etiology of acute exacerbations of chronic obstructive pulmonary disease was investigated and the diagnostic techniques used were compared among 92 hospitalized patients.

MATERIALS \& METHODS: Sputum specimens were investigated using culture and PCR, serological status evaluation was performed and the inflammatory profile was associated with the microbiological results.

RESULTS \& CONCLUSION: The majority of the patients (65.2\%) had very severe airway obstruction. The most common bacteria were Haemophilus influenzae and Pseudomonas aeruginosa (23.9 and 14.1\%, respectively). Acinetobacter baumannii- and P. aeruginosa-positive cultures were associated with prolonged hospitalization and severe airway obstruction (p = 0.03 and 0.031, respectively). Chlamydia pneumoniae or Mycoplasma pneumoniae infection was diagnosed in four and two patients, respectively. Discrepant results were detected between PCR and serology, especially regarding C. pneumoniae.},
	keywords = {Acinetobacter baumannii, Aged, Aged, 80 and over, Bacterial Typing Techniques, Chlamydophila pneumoniae, DNA, Bacterial, Female, Haemophilus influenzae, Hospitalization, Humans, Male, Middle Aged, Mycoplasma pneumoniae, polymerase chain reaction, Prospective Studies, Pseudomonas aeruginosa, Pulmonary Disease, Chronic Obstructive, Respiratory Tract Infections, Sputum},
	issn = {1746-0921},
	doi = {10.2217/fmb.14.90},
	author = {Nakou, Alexandra and Papaparaskevas, Joseph and Diamantea, Filia and Skarmoutsou, Nikoletta and Polychronopoulos, Vlasis and Tsakris, Athanassios}
}
