@article {Terpos2019,
	title = {{Consolidation therapy with the combination of bortezomib and lenalidomide (VR) without dexamethasone in multiple myeloma patients after transplant: Effects on survival and bone outcomes in the absence of bisphosphonates}},
	journal = {American Journal of Hematology},
	volume = {94},
	number = {4},
	year = {2019},
	month = {apr},
	pages = {400{\textendash}407},
	abstract = {Optimizing consolidation treatment in transplant-eligible newly diagnosed multiple myeloma patients in order to improve efficacy and bone-related outcomes is intriguing. We conducted an open-label, prospective study evaluating the efficacy and safety of bortezomib and lenalidomide (VR) consolidation after ASCT, in the absence of dexamethasone and bisphosphonates. Fifty-nine patients, who received bortezomib-based induction, were given 4 cycles of VR starting on day 100 post-ASCT. After ASCT, 58{\%} of patients improved their response status, while following VR consolidation 39{\%} further deepened their response; stringent complete response rates increased to 51{\%} after VR from 24{\%} post-ASCT. VR consolidation resulted in a significant reduction of soluble receptor activator of nuclear factor-${\k a}ppa$B ligand/osteoprotegerin ratio and sclerostin circulating levels, which was more pronounced among patients achieving very good partial response or better. After a median follow-up of 62 months, no skeletal-related events (SREs) were observed, despite the lack of bisphosphonates administration. The median TTP after ASCT was 37 months, while median overall survival (OS) has not been reached yet; the probability of 4- and 5-year OS was 81{\%} and 64{\%}, respectively. In conclusion, VR consolidation is an effective, dexamethasone- and bisphosphonate-free approach, which offers long OS with improvements on bone metabolism and no SREs.},
	issn = {03618609},
	doi = {10.1002/ajh.25392},
	url = {http://doi.wiley.com/10.1002/ajh.25392},
	author = {Terpos, Evangelos and Kastritis, Efstathios and Ntanasis-Stathopoulos, Ioannis and Christoulas, Dimitrios and Papatheodorou, Athanasios and Eleutherakis-Papaiakovou, Evangelos and Kanellias, Nikolaos and Fotiou, Despina and Ziogas, Dimitrios C. and Migkou, Magdalini and Roussou, Maria and Trougakos, Ioannis P. and Gavriatopoulou, Maria and Dimopoulos, Meletios A}
}
