@article {Gorgoulis2018,
	title = {{Integrating the DNA damage and protein stress responses during cancer development and treatment}},
	journal = {The Journal of Pathology},
	volume = {246},
	number = {1},
	year = {2018},
	month = {sep},
	pages = {12{\textendash}40},
	abstract = {During evolution, cells have developed a wide spectrum of stress response modules to ensure homeostasis. The genome and proteome damage response pathways constitute the pillars of this interwoven {\textquoteleft}defensive{\textquoteright} network. Consequently, the deregulation of these pathways correlates with ageing and various pathophysiological states, including cancer. In the present review, we highlight: (1) the structure of the genome and proteome damage response pathways; (2) their functional crosstalk; and (3) the conditions under which they predispose to cancer. Within this context, we emphasize the role of oncogene-induced DNA damage as a driving force that shapes the cellular landscape for the emergence of the various hallmarks of cancer. We also discuss potential means to exploit key cancer-related alterations of the genome and proteome damage response pathways in order to develop novel efficient therapeutic modalities. {\textcopyright} 2018 The Authors. The Journal of Pathology published by John Wiley {\&} Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.},
	keywords = {Cancer, DNA damage response, homeostasis, oncogenes, proteome damage response, Replication stress, stress response, tumor suppressors},
	issn = {00223417},
	doi = {10.1002/path.5097},
	url = {http://doi.wiley.com/10.1002/path.5097},
	author = {Gorgoulis, Vassilis G and Pefani, Dafni-Eleftheria and Pateras, Ioannis S and Trougakos, Ioannis P.}
}
