@booklet {17601,
	title = {Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology},
	journal = {Free Radical ResearchFree Radical Research},
	volume = {47},
	year = {2013},
	pages = {28-38},
	abstract = {Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed by the Maillard chemical process of non-enzymatic glycation of free amino groups of proteins, lipids and nucleic acids. This chemical modification of biomolecules is triggered by endogeneous hyperglycaemic or oxidative stress-related processes. Additionally, AGEs can derive from exogenous, mostly diet-related, sources. Considering that AGE accumulation in tissues correlates with ageing and is a hallmark in several age-related diseases it is not surprising that the role of AGEs in ageing and pathology has become increasingly evident. The receptor for AGEs (RAGE) is a single transmembrane protein being expressed in a wide variety of human cells. RAGE binds a broad repertoire of extracellular ligands and mediates responses to stress conditions by activating multiple signal transduction pathways being mostly responsible for acute and/or chronic inflammation. RAGE activation has been implicated in ageing as well as in a number of age-related diseases, including atherosclerosis, neurodegeneration, arthritis, stoke, diabetes and cancer. Here we present a synopsis of findings that relate to AGEs-reported implication in cell signalling pathways and ageing, as well as in pathology. Potential implications and opportunities for translational research and the development of new therapies are also discussed. {\textcopyright} 2013 Informa UK, Ltd.},
	keywords = {Ageing, AGEs, RAGE, Signalling, stress},
	isbn = {3021072747},
	url = {http://www.tandfonline.com/doi/full/10.3109/10715762.2013.806798},
	author = {Nedi{\'c}, O. and Rattan, S. I. S. and Grune, T. and Trougakos, I.P.}
}
