@booklet {17613,
	title = {Design, synthesis and antiproliferative activity of novel aminosubstituted benzothiopyranoisoindoles},
	journal = {Bioorganic \& Medicinal Chemistry LettersBioorganic \& Medicinal Chemistry Letters},
	volume = {21},
	year = {2011},
	pages = {3110-3112},
	publisher = {Elsevier Ltd},
	abstract = {The synthesis of a number of new benzothiopyrano[4,3,2-cd]isoindole aminoderivatives designed as structural analogues of the key metabolite of the anticancer agent Ledacrine (nitracrine) and their in vitro cytotoxic activity evaluation against HCT-116, MES-SA, and MES-SA/Dx cancer cell lines is reported. The majority of the derivatives possessed noticeable cytotoxicity in a low μM range indicating an interesting structure-activity relationship. {\textcopyright} 2011 Elsevier Ltd. All rights reserved.},
	keywords = {Cytotoxic activity, Fuzed isoindoles, Multi-drug resistance, Nitracrine, Thioxanthone analogues},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S0960894X11003404},
	author = {Christodoulou, Antonios and Kostakis, Ioannis K. and Kourafalos, Vassilios and Pouli, Nicole and Marakos, Panagiotis and Trougakos, Ioannis P. and Tsitsilonis, Ourania E.}
}
