@article {Campos2020,
	title = {{Osirisynes G-I, New Long-Chain Highly Oxygenated Polyacetylenes from the Mayotte Marine Sponge Haliclona sp.}},
	journal = {Marine Drugs},
	volume = {18},
	number = {7},
	year = {2020},
	month = {jul},
	pages = {350},
	abstract = {Chemical study of the CH2Cl2-MeOH (1:1) extract from the sponge Haliclona sp. collected in Mayotte highlighted three new long-chain highly oxygenated polyacetylenes, osirisynes G-I (1{\textendash}3) together with the known osirisynes A (4), B (5), and E (6). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS and MS/MS data. All compounds were evaluated on catalase and sirtuin 1 activation and on CDK7, proteasome, Fyn kinase, tyrosinase, and elastase inhibition. Five compounds (1; 3{\textendash}6) inhibited proteasome kinase and two compounds (5{\textendash}6) inhibited CDK7 and Fyn kinase. Osirisyne B (5) was the most active compound with IC50 on FYNB kinase, CDK7 kinase, and proteasome inhibition of 18.44 {\textmu}M, 9.13 {\textmu}M, and 0.26 {\textmu}M, respectively.},
	keywords = {Enzyme Inhibitors, Haliclona sp., Marine sponge, Oxygenated polyacetylenes},
	issn = {1660-3397},
	doi = {10.3390/md18070350},
	url = {https://www.mdpi.com/1660-3397/18/7/350},
	author = {Campos, Pierre-Eric and Herbette, Ga{\"e}tan and Chendo, Christophe and Clerc, Patricia and Tintillier, Florent and de Voogd, Nicole J. and Papanagnou, Eleni-Dimitra and Trougakos, Ioannis P. and Jerabek, Moran and Bignon, J{\'e}r{\^o}me and {Le Goff}, G{\'e}raldine and Ouazzani, Jamal and Gauvin-Bialecki, Anne}
}
