<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Terpos, Evangelos</style></author><author><style face="normal" font="default" size="100%">Kastritis, Efstathios</style></author><author><style face="normal" font="default" size="100%">Ntanasis-Stathopoulos, Ioannis</style></author><author><style face="normal" font="default" size="100%">Christoulas, Dimitrios</style></author><author><style face="normal" font="default" size="100%">Papatheodorou, Athanasios</style></author><author><style face="normal" font="default" size="100%">Eleutherakis-Papaiakovou, Evangelos</style></author><author><style face="normal" font="default" size="100%">Kanellias, Nikolaos</style></author><author><style face="normal" font="default" size="100%">Fotiou, Despina</style></author><author><style face="normal" font="default" size="100%">Ziogas, Dimitrios C.</style></author><author><style face="normal" font="default" size="100%">Migkou, Magdalini</style></author><author><style face="normal" font="default" size="100%">Roussou, Maria</style></author><author><style face="normal" font="default" size="100%">Trougakos, Ioannis P.</style></author><author><style face="normal" font="default" size="100%">Gavriatopoulou, Maria</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, Meletios A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">{Consolidation therapy with the combination of bortezomib and lenalidomide (VR) without dexamethasone in multiple myeloma patients after transplant: Effects on survival and bone outcomes in the absence of bisphosphonates}</style></title><secondary-title><style face="normal" font="default" size="100%">American Journal of Hematology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">apr</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://doi.wiley.com/10.1002/ajh.25392</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">4</style></number><volume><style face="normal" font="default" size="100%">94</style></volume><pages><style face="normal" font="default" size="100%">400–407</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Optimizing consolidation treatment in transplant-eligible newly diagnosed multiple myeloma patients in order to improve efficacy and bone-related outcomes is intriguing. We conducted an open-label, prospective study evaluating the efficacy and safety of bortezomib and lenalidomide (VR) consolidation after ASCT, in the absence of dexamethasone and bisphosphonates. Fifty-nine patients, who received bortezomib-based induction, were given 4 cycles of VR starting on day 100 post-ASCT. After ASCT, 58{%} of patients improved their response status, while following VR consolidation 39{%} further deepened their response; stringent complete response rates increased to 51{%} after VR from 24{%} post-ASCT. VR consolidation resulted in a significant reduction of soluble receptor activator of nuclear factor-$ąppa$B ligand/osteoprotegerin ratio and sclerostin circulating levels, which was more pronounced among patients achieving very good partial response or better. After a median follow-up of 62 months, no skeletal-related events (SREs) were observed, despite the lack of bisphosphonates administration. The median TTP after ASCT was 37 months, while median overall survival (OS) has not been reached yet; the probability of 4- and 5-year OS was 81{%} and 64{%}, respectively. In conclusion, VR consolidation is an effective, dexamethasone- and bisphosphonate-free approach, which offers long OS with improvements on bone metabolism and no SREs.</style></abstract></record></records></xml>