<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>13</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Christodoulou, Antonios</style></author><author><style face="normal" font="default" size="100%">Kostakis, Ioannis K.</style></author><author><style face="normal" font="default" size="100%">Kourafalos, Vassilios</style></author><author><style face="normal" font="default" size="100%">Pouli, Nicole</style></author><author><style face="normal" font="default" size="100%">Marakos, Panagiotis</style></author><author><style face="normal" font="default" size="100%">Trougakos, Ioannis P.</style></author><author><style face="normal" font="default" size="100%">Tsitsilonis, Ourania E.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Design, synthesis and antiproliferative activity of novel aminosubstituted benzothiopyranoisoindoles</style></title><secondary-title><style face="normal" font="default" size="100%">Bioorganic &amp; Medicinal Chemistry LettersBioorganic &amp; Medicinal Chemistry Letters</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Fuzed isoindoles</style></keyword><keyword><style  face="normal" font="default" size="100%">Multi-drug resistance</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitracrine</style></keyword><keyword><style  face="normal" font="default" size="100%">Thioxanthone analogues</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://linkinghub.elsevier.com/retrieve/pii/S0960894X11003404</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">Elsevier Ltd</style></publisher><volume><style face="normal" font="default" size="100%">21</style></volume><pages><style face="normal" font="default" size="100%">3110-3112</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The synthesis of a number of new benzothiopyrano[4,3,2-cd]isoindole aminoderivatives designed as structural analogues of the key metabolite of the anticancer agent Ledacrine (nitracrine) and their in vitro cytotoxic activity evaluation against HCT-116, MES-SA, and MES-SA/Dx cancer cell lines is reported. The majority of the derivatives possessed noticeable cytotoxicity in a low μM range indicating an interesting structure-activity relationship. © 2011 Elsevier Ltd. All rights reserved.</style></abstract><issue><style face="normal" font="default" size="100%">10</style></issue></record></records></xml>