<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Campos, Pierre-Eric</style></author><author><style face="normal" font="default" size="100%">Herbette, Gaëtan</style></author><author><style face="normal" font="default" size="100%">Chendo, Christophe</style></author><author><style face="normal" font="default" size="100%">Clerc, Patricia</style></author><author><style face="normal" font="default" size="100%">Tintillier, Florent</style></author><author><style face="normal" font="default" size="100%">de Voogd, Nicole J.</style></author><author><style face="normal" font="default" size="100%">Papanagnou, Eleni-Dimitra</style></author><author><style face="normal" font="default" size="100%">Trougakos, Ioannis P.</style></author><author><style face="normal" font="default" size="100%">Jerabek, Moran</style></author><author><style face="normal" font="default" size="100%">Bignon, Jérôme</style></author><author><style face="normal" font="default" size="100%">{Le Goff}, Géraldine</style></author><author><style face="normal" font="default" size="100%">Ouazzani, Jamal</style></author><author><style face="normal" font="default" size="100%">Gauvin-Bialecki, Anne</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">{Osirisynes G-I, New Long-Chain Highly Oxygenated Polyacetylenes from the Mayotte Marine Sponge Haliclona sp.}</style></title><secondary-title><style face="normal" font="default" size="100%">Marine Drugs</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Enzyme Inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">Haliclona sp.</style></keyword><keyword><style  face="normal" font="default" size="100%">Marine sponge</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxygenated polyacetylenes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">jul</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.mdpi.com/1660-3397/18/7/350</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">7</style></number><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">350</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Chemical study of the CH2Cl2−MeOH (1:1) extract from the sponge Haliclona sp. collected in Mayotte highlighted three new long-chain highly oxygenated polyacetylenes, osirisynes G-I (1–3) together with the known osirisynes A (4), B (5), and E (6). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS and MS/MS data. All compounds were evaluated on catalase and sirtuin 1 activation and on CDK7, proteasome, Fyn kinase, tyrosinase, and elastase inhibition. Five compounds (1; 3–6) inhibited proteasome kinase and two compounds (5–6) inhibited CDK7 and Fyn kinase. Osirisyne B (5) was the most active compound with IC50 on FYNB kinase, CDK7 kinase, and proteasome inhibition of 18.44 µM, 9.13 µM, and 0.26 µM, respectively.</style></abstract></record></records></xml>