Recent Publications

Mutation rate, genome size and their relation to the rec concept

Citation:

J. A. Heddle and Athanasiou, K., “Mutation rate, genome size and their relation to the rec concept”, Nature, vol. 258, no. 5533, pp. 359–361, 1975. Copy at http://www.tinyurl.com/2enswkqv

Abstract:

Abstract

ORGANISMS vary greatly in genome size, that is, in the amount of DNA comprising the haploid genome. Rates of radiation-induced mutation expressed as mutations per locus per rad, also differ widely among organisms, but it is surprising that mutation rates and genome size are correlated1. This correlation is unexpected because proteins are of a similar size in all organisms, implying that structural genes must also be of a similar size. Accordingly, one would expect that, although the overall mutation rate would be proportional to the overall number of genes, the mutation rate per locus would be similar in all organisms or, at least, bear no relation to genome size. Surveying published data, however, Abrahamson et al.1 found a direct correlation between rate of radiation-induced mutation and size of the haploid genome from Escherichia coli to Hordeum vulgare (the ABCW relationship). We wondered whether rates of chemically induced mutation would also be related to genome size, both because of the practical importance of being able to extrapolate to the genetic effect of a chemical on the human population and because the information might help to elucidate the mechanism underlying the ABCW relationship.

Notes:

Heddle, J. A., & Athanasiou, K. (1975). Mutation rate, genome size and their relation to the rec concept. Nature, 258(5533), 359-361. https://doi.org/10.1038/258359a0

Publisher's Version

EMS induced mutation rates and their relation to genome size

Citation:

K. Athanasiou and Heddle, J. A., “EMS induced mutation rates and their relation to genome size”, Canadian Journal of Genetics and Cytology, vol. 17, no. 3. NATL RESEARCH COUNCIL CANADA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A …, pp. 455-455, 1975. Copy at http://www.tinyurl.com/2d38una7

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Em. Professor

National and Kapodistrian University of Athens
(+30) 210-6930354
Navarinou str. 13A
Athens, ZipCode 10680
kathanas@ecd.uoa.gr

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Publications per year

2015 (2)
2014 (3)
2012 (5)
2011 (4)
2010 (1)
2009 (1)
2005 (1)
2003 (1)
2000 (2)
1997 (5)

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Kyriacos Athanasiou, Κυριάκος Αθανασίου,

Professor Emeritus, Early Childhood Education

Mutagenicity and clastogenicity of the antineoplastic agents homo-azasteroidal ester of p-bis (2-chloroethyl) aminophenyl acetic acid and chlorambucil [Mutation Res. 175 (1986) 165-169]

Citation:

Recent Publications

Mutation rate, genome size and their relation to the rec concept

Citation:

Abstract:

Abstract

Notes:

EMS induced mutation rates and their relation to genome size

Citation:

Em. Professor

Publications per year