@article {Papapanagiotou2019,
	title = {{The Use of Norethisterone for the Treatment of Severe Uterine Bleeding in Adolescents: An Audit of Our Experience}},
	journal = {Journal of Pediatric and Adolescent Gynecology},
	volume = {32},
	number = {6},
	year = {2019},
	abstract = {{\textcopyright} 2019 North American Society for Pediatric and Adolescent Gynecology Study Objective: The purpose of this prospective study was to assess the effectiveness of norethisterone (NET) in the management of abnormal uterine bleeding (AUB) in adolescents in a tertiary care center. Design: This was a prospective audit focused on administering high doses of NET in female adolescents with complaints of AUB. Setting: We included female adolescents who presented to our Emergency Gynecological Department or Adolescent Gynecological Outpatient Department from October 2016 to January 2019. Participants: The study included 29 female adolescents aged 11-17 (mean, 13.14) years. Interventions: Patients were administered a daily dose of 10-30 mg, depending on the severity of the condition, bleeding duration, and patient weight. Main Outcome Measures: Cessation of vaginal bleeding. Results: Mean age at menarche of our patient sample was 11.4 years (range, 10.7-14 years). AUB presented at a mean time of 24.6 months after menarche (range, 0-79 months). Blood transfusion was deemed necessary in 9 patients. Bleeding stopped at a mean of 46.1 (range, 8-120) hours after onset of treatment with NET. No serious adverse events were reported with NET administration, with only 3 cases of minor side effects. Conclusion: The use of NET is an effective and reliable treatment option among adolescents for whom control of AUB is desired in the acute setting.},
	keywords = {Abnormal uterine bleeding, Adolescents, AUB, Heavy menstrual bleeding, norethisterone},
	issn = {18734332},
	doi = {10.1016/j.jpag.2019.09.002},
	author = {Papapanagiotou, I.K. and Charamanta, M. and Roidi, S. and Al-Achmar, N.S. and Soldatou, A. and Michala, L.}
}
