@article {Nerantzoulis2017,
	title = {{Genital lichen sclerosus in childhood and adolescence{\textemdash}a retrospective case series of 15 patients: Early diagnosis is crucial to avoid long-term sequelae}},
	journal = {European Journal of Pediatrics},
	volume = {176},
	number = {10},
	year = {2017},
	abstract = {{\textcopyright} Springer-Verlag GmbH Germany 2017. Lichen sclerosus is a chronic skin disease, mainly localised at the introitus and perineum. When the condition remains untreated, gradual atrophy of skin structures leads to permanent scarring, making early diagnosis and treatment crucial. We reviewed all patients diagnosed with lichen sclerosus presenting to a tertiary referral centre for paediatric and adolescent gynaecology between January 2011 and December 2015 to assess disease presentation and response to treatment. We identified 15 cases, with a mean age at diagnosis of 8.8 years. Their main presenting symptoms were vulvar pruritus and vulvar soreness. Seven girls had already atrophic changes, and in four girls, this amounted to clitoral phimosis, labial resorption or labial adhesion formation. The median delay in diagnosis was 7 months. Thirteen patients received local treatment with potent corticosteroids, responding well to treatment. However, 4 girls relapsed within 2 to 36 months. Two adolescents required surgical treatment, one because of urinary retention and the second because of dyspareunia caused by clitoral entrapment. Conclusions: There was a delay in diagnosis in most patients and this resulted in irreversible genital skin changes, which would have been preventable, had treatment been instituted promptly. The response to treatment with local corticosteroids was usually effective, leading to both symptom alleviation and prevention of disease progression. Atrophic changes and skin complications however were not reversed.},
	keywords = {Adolescents, Case series, Children, lichen sclerosus, Phimosis, Vulvar atrophy},
	issn = {14321076},
	doi = {10.1007/s00431-017-3004-y},
	author = {Nerantzoulis, I. and Grigoriadis, T and Michala, L.}
}
