@article { WOS:000281995200013,
	title = {Power law IVIVC: An application of fractional kinetics for drug release and absorption},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {41},
	number = {2},
	year = {2010},
	month = {OCT 9},
	pages = {299-304},
	publisher = {ELSEVIER},
	type = {Article},
	address = {RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS},
	abstract = {Most correlations between in vitro and in vivo data (IVIVC) rely on linear relationships. However, non-linear IVIVC can be also observed, justified and validated. The purpose of the present work was the development of a methodology for power law IVIVC, which mirror power law kinetics under in vitro and in vivo conditions. Fractional calculus was used to justify power law kinetics for zero-order processes in disordered media. Power law kinetics was observed in a large number of in vitro data sets. When {\textquoteleft}{\textquoteleft}zero-order{{\textquoteright}{\textquoteright}} release and absorption is considered in terms of fractional calculus the following power law IVIVC between the fraction released F-r and the fraction absorbed F-alpha, is obtained: F-alpha = mu F-r(lambda) - beta, where mu is a constant related to the rate constants and the orders of the release/absorption kinetics, lambda is the ratio of the orders of the kinetics under in vitro and in vivo conditions and 13 accounts for a time shift between the in vitro and in vivo processes; We used literature data to develop power law IVIVC and derive estimates for mu, lambda and beta; the simulated pharmacokinetic profiles using the in vitro release data and the IVIVC developed compared well with the actual in vivo data. (C) 2010 Elsevier B.V. All rights reserved.},
	keywords = {Drug release, Fractional kinetics, IVIVC, Power law},
	issn = {0928-0987},
	doi = {10.1016/j.ejps.2010.06.015},
	author = {Kytariolos, John and Dokoumetzidis, Aristides and Macheras, Panos}
}
