@article { WOS:000232845200007,
	title = {Bicompartmental kinetics of tobramycin analysed with a wide range of covariates},
	journal = {INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS},
	volume = {26},
	number = {4},
	year = {2005},
	month = {OCT},
	pages = {304-311},
	publisher = {ELSEVIER},
	type = {Article},
	address = {RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS},
	abstract = {{The pharmacokinetics of tobramycin was studied in adult patients (N = 151) admitted either for initial suspicion of Gram-negative infection or for prophylaxis. In addition to age, weight, height and creatinine clearance (CrCL), a range of other covariates were also analysed, including type of pathology, co-medication, fever, sex and ethnicity (Basque or not). All patients received 100 mg tobramycin every 8 h and samples were collected at three time points after the first dose and at two time points after the fourth dose and assayed with a fluorescence polarisation immunoassay. The population mixed effects bicompartmental parameters were obtained from 725 concentration measurements using NONMEM, FOCE method, and were: systemic clearance},
	keywords = {covariates, MONTE CARLO, NONMEM, pharmacodynamics, population pharmacokinetics, tobramycin},
	issn = {0924-8579},
	doi = {10.1016/j.ijantimicag.2005.05.004},
	author = {Inclan, G and Suarez, E and Calvo, R and Aguirre, C and Macheras, P. and Gazouli, M. and Lukas, JC}
}
