@article { WOS:000225137300014,
	title = {Pharmacokinetics of teicoplanin in an ICU population of children and infants},
	journal = {PHARMACEUTICAL RESEARCH},
	volume = {21},
	number = {11},
	year = {2004},
	month = {NOV},
	pages = {2064-2071},
	publisher = {KLUWER ACADEMIC/PLENUM PUBL},
	type = {Article},
	address = {233 SPRING ST, NEW YORK, NY 10013 USA},
	abstract = {{Purpose. Better dosing is needed for antibiotics, including teicoplanin (TEI), to prevent emergence of resistant bacterial strains. Here, we assess the TEI pharmacokinetics (PK) related to a 10 mg/l minimum inhibitory concentration (MIC) target in ICU children (4 to 120 months; n=20) with gram+infections. Methods. Standard administration of TEI was with three 10 mg/kg Q12h, loading infusions, and maintainance with 10 mg/kg or 15 mg/kg Q24h. During maintenance, 9 samples (3/day) were collected per patient and the PK analyzed with Nonlinear Mixed Effects Model (NONMEM). Results. Thirty-five percent of concentrations in older children (greater than or equal to2 months) vs. 8\% in younger infants (<12 months) were below the target MIC. The global bicompartmental population PK parameters were {[}mean (interindividual CV\%)] CL=0.23 l/h {[}72\%]},
	keywords = {Children, infants, NONMEM, Pharmacokinetics, simulation, Teicoplanin},
	issn = {0724-8741},
	doi = {10.1023/B:PHAM.0000048198.56873.d8},
	author = {Lukas, JC and Karikas, G and Gazouli, M. and Kalabalikis, P and Hatzis,T. and Macheras, P.}
}
