@article { WOS:A1992GY52000015,
	title = {COMPLEXATION STUDIES OF CYCLODEXTRINS WITH TRICYCLIC ANTIDEPRESSANTS USING ION-SELECTIVE ELECTRODES},
	journal = {PHARMACEUTICAL RESEARCH},
	volume = {9},
	number = {1},
	year = {1992},
	month = {JAN},
	pages = {94-100},
	publisher = {PLENUM PUBL CORP},
	type = {Article},
	address = {233 SPRING ST, NEW YORK, NY 10013},
	abstract = {The complexation of six tricyclic antidepressant drugs {[}amitriptylin (AMN), nortriptylin (NRN), imipramin (IMN), doxepin (DXN), protriptylin (PTN), and maprotilin (MPN)] with alpha-and-beta-cyclodextrins (CDs) using ion-selective electrodes (ISEs) as drug ion sensors is described. Binding parameters were calculated by nonlinear fitting of the model described by the Scatchard equation, to the experimental data of a titration of a CD solution with the ion of interest. One binding site (the CD cavity) was found in all cases with both CDs. The calculated association constants at 25-degrees-C using CD concentrations in the range of 0.0100-0.0010 M, varied from 4.81 x 10(3) M-1 (MPN) to 23.9 x 10(3) M-1 (AMN) in the case of beta-CD and from 50 M-1 (DXN) to 123 M-1 (MPN) in the case of alpha-CD. The precision for the estimation of the binding parameters was 0.1-5.0\% (within-run RSD\%) and 8-10\% (between-run RSD\%; n = 3). The complexation of the drugs with beta-CD was also examined as a function of temperature in the range of 5-37-degrees-C; it was found to decrease by increasing temperature. Van{\textquoteright}t Hoff analysis gave good correlations (r greater-than-or-equal-to 0.989) for all drug ions studied. The estimates of the thermodynamic parameters indicate that the formation of inclusion complexes is enthalpy driven. A compensation plot based on the thermodynamic parameters DELTA-H and DELTA-S resulted in a linear relationship, which is indicative of a common type of force involved in the complexation of drugs to beta-CD.},
	keywords = {complex formation, cyclodextrins, INCLUSION COMPLEXES, ion-selective electrodes, TRICYCLIC ANTIDEPRESSANTS},
	issn = {0724-8741},
	doi = {10.1023/A:1018940013006},
	author = {Valsami, GN and Koupparis, MA and Macheras, PE}
}
