<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Charkoftaki, Georgia</style></author><author><style face="normal" font="default" size="100%">Kytariolos, John</style></author><author><style face="normal" font="default" size="100%">Macheras, Panos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel milk-based oral formulations: Proof of concept</style></title><secondary-title><style face="normal" font="default" size="100%">INTERNATIONAL JOURNAL OF PHARMACEUTICS</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aspirin</style></keyword><keyword><style  face="normal" font="default" size="100%">Cyclosporine</style></keyword><keyword><style  face="normal" font="default" size="100%">Danazol</style></keyword><keyword><style  face="normal" font="default" size="100%">milk</style></keyword><keyword><style  face="normal" font="default" size="100%">NSAIDs</style></keyword><keyword><style  face="normal" font="default" size="100%">Oral formulations</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2010</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAY 10</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">2</style></number><publisher><style face="normal" font="default" size="100%">ELSEVIER</style></publisher><pub-location><style face="normal" font="default" size="100%">RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS</style></pub-location><volume><style face="normal" font="default" size="100%">390</style></volume><pages><style face="normal" font="default" size="100%">150-159</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The aim of this study is to develop milk-based formulations for ionized and unionized lipophilic drugs. Solubility studies of the following non-steroidal anti-inflammatory drugs (NSAIDs): mefenamic acid, tolfenamic acid, ketoprofen, meloxicam, tenoxicam and nimesulide in phosphate- and glycine-NaOH buffers at nominal pH 8-12. were performed. The solubilities of cyclosporine and danazol in water-ethanol solutions were studied. NSAIDs-, cyclosporine-, danazol-, aspirin-milk oral liquid formulations were prepared by adding the appropriate volume of (i) NSAIDs-alkaline buffer solutions, (ii) water-ethanol solutions of cyclosporine and danazol and (iii) aspirin aqueous solution to 150-200 ml of milk. All the non-steroidal anti-inflammatory drugs exhibited increased solubility in the alkaline buffers. The actual pH values (range 6.7-7.7) of the final NSAIDs-milk formulations were very close to milk pH. The higher ethanol content in ethanol-water mixtures increased the solubility of danazol and cyclosporine. A 15 mg meloxicam-, a 100 mg cyclosporine- and a 500 mg aspirin-milk formulation was administered orally to healthy volunteers. All these formulations showed a satisfactory in vivo performance. The strong buffering capacity of milk that was observed and the high solubility of unionized drugs in ethanol allow the preparation of drug-milk formulations with enhanced pharmacokinetic properties. (C) 2010 Elsevier B.V. All rights reserved.</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type></record></records></xml>