<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Macheras, P.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">CARRIER-MEDIATED TRANSPORT CAN OBEY FRACTAL KINETICS</style></title><secondary-title><style face="normal" font="default" size="100%">PHARMACEUTICAL RESEARCH</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CARRIER-MEDIATED TRANSPORT</style></keyword><keyword><style  face="normal" font="default" size="100%">FRACTAL DIMENSION</style></keyword><keyword><style  face="normal" font="default" size="100%">Fractal kinetics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">1995</style></year><pub-dates><date><style  face="normal" font="default" size="100%">APR</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">4</style></number><publisher><style face="normal" font="default" size="100%">PLENUM PUBL CORP</style></publisher><pub-location><style face="normal" font="default" size="100%">233 SPRING ST, NEW YORK, NY 10013</style></pub-location><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">541-548</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">A model based on the fractal methodology is proposed for the kinetic study of carrier-mediated transport under heterogeneous conditions, i.e., when the drug-carrier interaction occurs at an interface with an effective dimensionality smaller than the embedding dimension of d = 2. A model equation is derived for the flux, based on a similar approach for an analogous equation for enzyme kinetics. It is shown that the total flux-solute concentration plots are curvilinear when the fractal dimension is smaller than unity while they become biexponential, with ascending and descending limbs, when the fractal dimension D is in the range 1 &lt; D &lt; 2. Nonlinear Lineweaver-Burk plots are obtained when this fractal kinetics approach is used. Good fittings are obtained when the fractal model is applied to literature data previously analysed with a combined transport mechanism, revealing experimental systems that display a D value in the range 1 &lt; D &lt; 2. It is suggested that transport studies should be carried out at a wider working solute concentration range and various agitation and incubation conditions in order to derive definite conclusions for the transport pathways.</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type></record></records></xml>