@article {10182,
	title = {Ovarian SAHA syndrome is associated with a more insulin-resistant profile and represents an independent risk factor for glucose abnormalities in women with polycystic ovary syndrome: a prospective controlled study.},
	journal = {J Am Acad Dermatol},
	volume = {69},
	year = {2013},
	month = {2013 Dec},
	pages = {922-30},
	abstract = {BACKGROUND: SAHA syndrome is characterized by the tetrad: seborrhea, acne, hirsutism, and androgenetic alopecia. No previous study has examined the prevalence of glucose abnormalities in ovarian SAHA and explored whether it may be an independent risk factor for glucose abnormalities.

OBJECTIVE: In a prospective controlled study, we investigated the spectrum of glucose abnormalities in ovarian SAHA and explored whether it is associated with a more insulin-resistant profile.

METHODS: In all, 316 patients with a diagnosis of polycystic ovary syndrome (PCOS) (56 with SAHA) and 102 age-matched healthy women were examined and underwent a 2-hour oral glucose tolerance test. Serum glucose homeostasis parameters, hormones, and adipokines were determined.

RESULTS: SAHA prevalence was 17.7\% in patients with PCOS and predominance of the severe PCOS phenotype. Ovarian SAHA was independently associated with a more insulin-resistant profile (higher homeostatic model assessment of insulin resistance score, lower quantitative insulin sensitivity check index [QUICKI] and MATSUDA indices, and relative hypoadiponectinemia), and represented an independent risk factor for glucose abnormalities regardless of anthropometric features, age, and PCOS phenotype.

LIMITATION: There was no performance of skin biopsies.

CONCLUSION: The prompt recognition of SAHA syndrome in women with PCOS permits an earlier diagnosis and surveillance of metabolic abnormalities, especially in Mediterranean PCOS population exhibiting a lower prevalence of glucose abnormalities.},
	keywords = {Acne Vulgaris, Adolescent, Adult, Alopecia, Dermatitis, Seborrheic, Female, Glucose, hirsutism, Humans, Insulin Resistance, Ovarian Diseases, Polycystic ovary syndrome, Prospective Studies, Risk Factors, Syndrome, Young Adult},
	issn = {1097-6787},
	doi = {10.1016/j.jaad.2013.09.014},
	author = {Dalamaga, Maria and Papadavid, Evangelia and Basios, Georgios and Vaggopoulos, Vassilios and Rigopoulos, Dimitrios and Kassanos, Dimitrios and Trakakis, Eftihios}
}
