@article {10192,
	title = {Prevalence of non classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency in Greek women with acne: a hospital-based cross-sectional study.},
	journal = {J Eur Acad Dermatol Venereol},
	volume = {27},
	year = {2013},
	month = {2013 Nov},
	pages = {1448-51},
	abstract = {AIM: To determine the prevalence and frequency of non classical congenital adrenal hyperplasia (NC-CAH) due to 21-OHD at the time of clinical presentation and at the peripubertal period in a substantial sample of Greek women with acne and to investigate the correlation of serum T, 17-OHP and DHEA-S with acne appearance at the time of clinical presentation.

METHODS: One hundred and twenty-three unselected women with hyperandrogenemic symptoms were examined. After the ACTH stimulation test, 6 (4.9\%) women were diagnosed with NC-CAH due to 21-OHD.

RESULTS: There was not any statistical significant difference in the frequency of peripubertal acne between NC-CAH group of patients (6.4\%) and patients with hyperandrogenemia of other aetiology (93\%), mainly ovarian (P = 0.41). However, there was a statistical significant difference in the prevalence of acne at the time of clinical examination between the two groups (P = 0.04). Acne was present in 83.3\% of women with NC-CAH vs. 41.02\% of women in the hyperandrogenic group without NC-CAH. A statistically significant decrease of acne from the peripubertal time to the time of clinical examination in the group of women with hyperandrogenemia of other aetiology (-21.37\%) was observed compared to women with NC-CAH (P < 0.001).

CONCLUSION: We have shown that acne persists from peripubertal period to adult life in NC-CAH women whereas it tends to diminish in women with hyperandrogenemia of other aetiology. Acne is a prominent finding in women with NC-CAH. Serum concentrations of 17-OHP after ACTH stimulation (17-OHP6O ) should be investigated in women with persistent acne in adult life.},
	keywords = {Acne Vulgaris, Adolescent, Adrenal Hyperplasia, Congenital, Adult, Cross-Sectional Studies, Female, Greece, Hospitals, Humans, Prevalence, Young Adult},
	issn = {1468-3083},
	doi = {10.1111/j.1468-3083.2012.04613.x},
	author = {Trakakis, E. and Papadavid, E and Dalamaga, M and Koumaki, D and Stavrianeas, N and Rigopoulos, D and Creatsas, G. and Kassanos, D.}
}
