@article {10206,
	title = {Ischemia modified albumin, high-sensitivity c-reactive protein and natriuretic peptide in patients with coronary atherosclerosis.},
	journal = {Clin Chim Acta},
	volume = {408},
	year = {2009},
	month = {2009 Oct},
	pages = {65-9},
	abstract = {BACKGROUND: Ischemia modified albumin (IMA), is a new biomarker of oxidative processes involved with coronary artery disease (CAD). We determined serum IMA, high-sensitivity C-reactive protein (hsCRP), and natriuretic peptide (NT-proBNP), and evaluated their correlation with severity of coronary atherosclerosis in patients undergoing coronary angiography (CA). Cardiac troponin T (cTnT), CK-MB mass, albumin and Total Antioxidant Status (TAS) were also evaluated.

METHODS: The study included 114 patients (88 men and 30 women) aged 43-80 years with documented CAD without evidence of acute coronary syndrome undergoing CA and 163 controls (131 men and 32 women) similarly aged.

RESULTS: IMA, hsCRP and NT-proBNP were higher (p<0.001 and p=0.008 for NT-proBNP) while TAS was lower (p<0.001) in patients than in controls. IMA and TAS were negatively correlated in all subjects (p<0.01). Among patients, there was no correlation between IMA and the number of diseased vessels. For CAD diagnosis the best cut-off point for IMA was 101.5 KU/L with a sensitivity and a specificity of 87.7\% and a negative predictive value of 83.3\%. IMA was associated with an increased risk for CAD (OR=1.23, 95\% CI: 1.16-1.31; p<0.001).

CONCLUSIONS: IMA determination may provide earlier information of CAD presence before hsCRP or NT-proBNP elevation, contributing to early assessment of overall patient risk.},
	keywords = {Adult, Aged, Aged, 80 and over, Antioxidants, Biomarkers, C-Reactive Protein, Case-Control Studies, Coronary Angiography, Coronary artery disease, Female, Humans, Male, Middle Aged, Natriuretic Peptides, Necrosis, Serum albumin, Troponin T},
	issn = {1873-3492},
	doi = {10.1016/j.cca.2009.07.007},
	author = {Kazanis, Konstantinos and Dalamaga, Maria and Nounopoulos, Charalampos and Manolis, Antonios S and Sakellaris, Nikolaos and Jullien, Gerard and Dionyssiou-Asteriou, Amalia}
}
