@article {10209,
	title = {Circulating oxidized LDL levels, current smoking and obesity in postmenopausal women.},
	journal = {Atherosclerosis},
	volume = {205},
	year = {2009},
	month = {2009 Jul},
	pages = {279-83},
	abstract = {OBJECTIVE: The aim of the present study was to estimate circulating oxidized low-density lipoprotein (oxLDL) levels in postmenopausal women and evaluate their association with obesity and smoking status.

DESIGN AND METHODS: The study included 135 postmenopausal women aged 52-75 years. Forty of them were overweight (BMI 32.4+/-6.4) and non-smokers (Group A), 40 non-overweight (BMI 22.6+/-1.8) and smokers (Group B) and 55 non-overweight (BMI 23.5+/-1.4) and non-smokers (Group C). oxLDL and antibodies against them (anti-oxLDL) were measured using ELISA. Serum total cholesterol, LDL, HDL and triglycerides were measured in an automated analyzer.

RESULTS: Total cholesterol, LDL, HDL and oxLDL serum levels were significantly elevated in Group A as compared to Group B or C, as well as oxLDL in Group B in comparison to Group C (p<0.001). Triglycerides and anti-oxLDL were increased in Group A in comparison to Group C (p=0.043 and 0.023). Total cholesterol, LDL, triglycerides and anti-oxLDL did not differ between Groups B and C, while HDL was decreased in Group B as compared to Group C (p<0.001). A significant positive correlation was found between oxLDL and LDL in Group A (r=0.53, p<0.001) as well as in Group C (r=0.955, p<or=0.001) and a negative one between oxLDL and HDL in Group C (r=-0.933, p<0.001). Regression analysis revealed that obesity was a stronger predictor of LDL oxidation than smoking.

CONCLUSIONS: Postmenopausal obesity is involved in the process of LDL oxidation and appears to be a stronger predictor of LDL oxidation than smoking. Future studies are needed to confirm these associations.},
	keywords = {Aged, Body Mass Index, Female, Humans, Lipoproteins, LDL, Middle Aged, Obesity, POSTMENOPAUSE, Regression Analysis, Risk Factors, Smoking, Tobacco Use Disorder},
	issn = {1879-1484},
	doi = {10.1016/j.atherosclerosis.2008.11.006},
	author = {Kassi, E and Dalamaga, M and Faviou, E and Hroussalas, G and Kazanis, K and Nounopoulos, Ch and Dionyssiou-Asteriou, A}
}
