@article {10345,
	title = {<span style="font-size: 12.0pt; font-family: {\textquoteright}Times New Roman{\textquoteright},serif; mso-fareast-font-family: {\textquoteright}Times New Roman{\textquoteright}; mso-ansi-language: EN-US; mso-fareast-language: EL; mso-bidi-language: AR-SA;">Nicotinamide phopshoribosyltranferase (NAMPT_ 7q22.3).</span>},
	journal = {Atlas Genet Cytogenet Oncol Haematol.},
	volume = {16},
	year = {2012},
	pages = {909-912},
	abstract = {<p>Because of its pivotal role in the recycling pathway allowing NAD generation from nicotinamide, NAMPT occupies a central position in controlling the activity of several NAD-dependent enzymes. NAD, a universal energy-and signal-carrying molecule and its phosphorylated form, NADP, are required in several intracellular processes such as redox reactions, DNA repair, G-protein coupled receptor signaling, intra-cellular calcium-mobilizing molecules, transcriptional regulation, mono-adenosine diphosphate (ADP)-ribosylation in immune response, and activity of poly-ADP ribosyltransferases and deacetylases (sirtuins) with roles in regulating cell survival and cytokine responses. Under the influence of NAMPT, adequate levels of NAD control SIRT-6 (sirtuin) activity, which in turn positively regulates TNF-α mRNA translation favoring cell survival. NAMPT activity enhances cellular proliferation, tips the balance toward cellular survival following a genotoxic insult and controls the circadian clock machinery of some key transcriptions factors.</p>},
	author = {Koumaki, V and Dalamaga, M}
}
