<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Karampela, Irene</style></author><author><style face="normal" font="default" size="100%">Kandri, Evangelia</style></author><author><style face="normal" font="default" size="100%">Antonakos, Georgios</style></author><author><style face="normal" font="default" size="100%">Vogiatzakis, Evangelos</style></author><author><style face="normal" font="default" size="100%">Christodoulatos, Gerasimos Socrates</style></author><author><style face="normal" font="default" size="100%">Nikolaidou, Athina</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, George</style></author><author><style face="normal" font="default" size="100%">Armaganidis, Apostolos</style></author><author><style face="normal" font="default" size="100%">Dalamaga, Maria</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Kinetics of circulating fetuin-A may predict mortality independently from adiponectin, high molecular weight adiponectin and prognostic factors in critically ill patients with sepsis: A prospective study.</style></title><secondary-title><style face="normal" font="default" size="100%">J Crit Care</style></secondary-title><alt-title><style face="normal" font="default" size="100%">J Crit Care</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017 Oct</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">41</style></volume><pages><style face="normal" font="default" size="100%">78-85</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">PURPOSE: Fetuin-A and adiponectin, major hepatokine and adipokine respectively, have been implicated in systematic inflammation. Our aim was to jointly investigate whether kinetics of circulating fetuin-A, adiponectin and its isoform HMWA predict 28-day mortality in sepsis.

MATERIALS AND METHODS: In a prospective study, serum fetuin-A, adiponectin and HMWA were determined in 102 ICU patients fulfilling the diagnostic criteria of SEPSIS-3, at enrollment and one week after, and in 102 healthy controls matched on age and gender.

RESULTS: Serum fetuin-A was significantly lower in septic patients than controls (p&lt;0.001). Among septic patients, those with septic shock and nonsurvivors presented lower fetuin-A, but higher adiponectin and HMWA compared to patients with sepsis and survivors respectively, both at baseline and day 7 (p&lt;0.001). Fetuin-A exhibited negative correlations with APACHE II, CRP, procalcitonin, adiponectin and IL-6 but a positive one with albumin. Reduced fetuin-A as well as lower serum kinetics of fetuin-A (HR: 0.55, 95% C.I. 0.34-0.91, p=0.02), adiponectin but not HMWA were independently associated with 28-day mortality adjusting for age, gender, BMI, APACHE II, septic shock and laboratory biomarkers.

CONCLUSIONS: Circulating fetuin-A kinetics may be a prognostic biomarker in septic patients. More research is essential to elucidate fetuin-A's ontological role in sepsis pathophysiology.</style></abstract><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/28500919?dopt=Abstract</style></custom1></record></records></xml>