<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vlachos, C.a b</style></author><author><style face="normal" font="default" size="100%">Schulte, B.M.a</style></author><author><style face="normal" font="default" size="100%">Magiatis, P.c</style></author><author><style face="normal" font="default" size="100%">Adema, G.J.a</style></author><author><style face="normal" font="default" size="100%">Gaitanis, G.b</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Malassezia-derived indoles activate the aryl hydrocarbon receptor and inhibit Toll-like receptor-induced maturation in monocyte-derived dendritic cells</style></title><secondary-title><style face="normal" font="default" size="100%">British Journal of Dermatology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2 b]carbazole</style></keyword><keyword><style  face="normal" font="default" size="100%">alloimmunity</style></keyword><keyword><style  face="normal" font="default" size="100%">aromatic hydrocarbon receptor</style></keyword><keyword><style  face="normal" font="default" size="100%">article</style></keyword><keyword><style  face="normal" font="default" size="100%">Aryl Hydrocarbon</style></keyword><keyword><style  face="normal" font="default" size="100%">Aryl Hydrocarbon Hydroxylases</style></keyword><keyword><style  face="normal" font="default" size="100%">B7 antigen</style></keyword><keyword><style  face="normal" font="default" size="100%">Carbazoles</style></keyword><keyword><style  face="normal" font="default" size="100%">CD83 antigen</style></keyword><keyword><style  face="normal" font="default" size="100%">CD86 antigen</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Aging</style></keyword><keyword><style  face="normal" font="default" size="100%">cell function</style></keyword><keyword><style  face="normal" font="default" size="100%">cell maturation</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Proliferation</style></keyword><keyword><style  face="normal" font="default" size="100%">Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">controlled study</style></keyword><keyword><style  face="normal" font="default" size="100%">Cultured</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytochrome P-450 CYP1A1</style></keyword><keyword><style  face="normal" font="default" size="100%">cytochrome P450 1A1</style></keyword><keyword><style  face="normal" font="default" size="100%">cytochrome P450 1B1</style></keyword><keyword><style  face="normal" font="default" size="100%">dendritic cell</style></keyword><keyword><style  face="normal" font="default" size="100%">Dendritic Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">gene expression</style></keyword><keyword><style  face="normal" font="default" size="100%">human</style></keyword><keyword><style  face="normal" font="default" size="100%">human cell</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">indirubin</style></keyword><keyword><style  face="normal" font="default" size="100%">indole derivative</style></keyword><keyword><style  face="normal" font="default" size="100%">Indoles</style></keyword><keyword><style  face="normal" font="default" size="100%">indolo[3</style></keyword><keyword><style  face="normal" font="default" size="100%">interleukin 12</style></keyword><keyword><style  face="normal" font="default" size="100%">interleukin 6</style></keyword><keyword><style  face="normal" font="default" size="100%">Interleukin-12</style></keyword><keyword><style  face="normal" font="default" size="100%">Interleukin-6</style></keyword><keyword><style  face="normal" font="default" size="100%">major histocompatibility antigen class 2</style></keyword><keyword><style  face="normal" font="default" size="100%">Malassezia</style></keyword><keyword><style  face="normal" font="default" size="100%">malassezin</style></keyword><keyword><style  face="normal" font="default" size="100%">monocyte</style></keyword><keyword><style  face="normal" font="default" size="100%">Monocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">nonhuman</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenotype</style></keyword><keyword><style  face="normal" font="default" size="100%">priority journal</style></keyword><keyword><style  face="normal" font="default" size="100%">Quinazolines</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptors</style></keyword><keyword><style  face="normal" font="default" size="100%">T lymphocyte</style></keyword><keyword><style  face="normal" font="default" size="100%">toll like receptor</style></keyword><keyword><style  face="normal" font="default" size="100%">toll like receptor agonist</style></keyword><keyword><style  face="normal" font="default" size="100%">Toll-Like Receptors</style></keyword><keyword><style  face="normal" font="default" size="100%">tryptanthrin</style></keyword><keyword><style  face="normal" font="default" size="100%">unclassified drug</style></keyword><keyword><style  face="normal" font="default" size="100%">upregulation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.scopus.com/inward/record.url?eid=2-s2.0-84865607255&amp;partnerID=40&amp;md5=fca65a0cb30665618bebb981ed96ba11</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">3</style></number><volume><style face="normal" font="default" size="100%">167</style></volume><pages><style face="normal" font="default" size="100%">496-505</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Background The aryl hydrocarbon receptor (AhR) is a nuclear receptor and transcriptional regulator with pleiotropic effects. The production of potent AhR ligands by Malassezia yeasts, such as indirubin, indolo[3,2-b]carbazole (ICZ), tryptanthrin and malassezin, has been associated with the pathogenesis of seborrhoeic dermatitis and pityriasis versicolor. Antigen-presenting cells in the skin can encounter microbes in the presence of these bioactive metabolites that could potentially modulate their function. Objectives To study the effects of the aforementioned naturally occurring ligands on AhR activation and Toll-like receptor (TLR)-induced maturation in human monocyte-derived dendritic cells (moDCs). Methods These indoles were screened for AhR activation capacity in moDCs employing CYP1A1 and CYP1B1 induction as read out and for their effects on the function of moDCs after TLR-ligand stimulation. Results Indirubin and ICZ were the most potent AhR ligands and were selected for subsequent experiments. Concurrent exposure of moDCs to indirubin or ICZ together with TLR agonists significantly augmented the AhR-mediated CYP1A1 and CYP1B1 gene expression. Additionally, mature DCs that were subsequently stimulated with AhR ligands showed increased AhR target gene expression. Moreover, these ligands limited TLR-induced phenotypic maturation (CD80, CD83, CD86, MHC II upregulation) of moDCs, reduced secretion of the inflammatory cytokines interleukin (IL)-6 and IL-12, and decreased their ability to induce alloreactive T-lymphocyte proliferation. Conclusions These results demonstrate that AhR agonists of yeast origin are able to inhibit moDC responses to TLR ligands and that moDCs can adapt through increased transcription of metabolizing enzymes such as CYP1A1 and CYP1B1. © 2012 British Association of Dermatologists.</style></abstract><notes><style face="normal" font="default" size="100%">cited By (since 1996)5</style></notes></record></records></xml>