@article {ijms232314972,
	title = {First Trimester Maternal Plasma Aberrant miRNA Expression Associated with Spontaneous Preterm Birth},
	journal = {International Journal of Molecular Sciences},
	volume = {23},
	number = {23},
	year = {2022},
	pages = {14972},
	abstract = {Spontaneous Preterm Delivery (sPTD) is one of the leading causes of perinatal mortality and morbidity worldwide. The present case{\textendash}control study aims to detect miRNAs differentially expressed in the first trimester maternal plasma with the view to identify predictive biomarkers for sPTD, between 320/7 and 366/7 weeks, that will allow for timely interventions for this serious pregnancy complication. Small RNA sequencing (small RNA-seq) of five samples from women with a subsequent sPTD and their matched controls revealed significant down-regulation of miR-23b-5p and miR-125a-3p in sPTD cases compared to controls, whereas miR-4732-5p was significantly overexpressed. Results were confirmed by qRT-PCR in an independent cohort of 29 sPTD cases and 29 controls. Statistical analysis demonstrated that miR-125a is a promising early predictor for sPTL (AUC: 0.895; 95\% CI: 0.814-0.972; p \&lt; 0.001), independent of the confounding factors tested, providing a useful basis for the development of a novel non-invasive predictive test to assist clinicians in estimating patient-specific risk.},
	issn = {1422-0067},
	doi = {10.3390/ijms232314972},
	author = {Mavreli, Danai and Theodora, Mariana and Avgeris, Margaritis and Papantoniou, Nikolas and Antsaklis, Panagiotis and Daskalakis, George and Kolialexi, Aggeliki}
}
