@article {44681,
	title = {Lifestyle and Biochemical Parameters That May Hamper Immune Responses in Pediatric Patients After Immunization with the BNT162b2 mRNA COVID-19 Vaccine},
	journal = {Diseases},
	volume = {13},
	number = {3},
	year = {2025},
	note = {Damianaki, AnthieMarmarinos, AntoniosAvgeris, MargaritisGourgiotis, DimitriosVlachopapadopoulou, Elpis-AthinaCharakida, MariettaTsolia, MariaKossiva, Lydiaeng5000 EURO/BANK OF GREECE/Switzerland2025/03/26 12:30Diseases. 2025 Mar 10;13(3):78. doi: 10.3390/diseases13030078.},
	month = {Mar 10},
	abstract = {BACKGROUND: The aim of this study was to evaluate whether increased body mass index (BMI) and biochemical and lifestyle parameters linked to obesity and smoke exposure disrupt immune responses of children and adolescents following vaccination with the mRNA BNT162b2 vaccine. METHODS: A prospective, single-center, cohort study was conducted. Participants were assigned to receive two doses of the mRNA vaccine. Anti-SARS-CoV-2 IgG and neutralizing antibodies (AB) were measured before vaccination (T0) and 14 days after the second dose (T1). BMI and biochemical parameters were evaluated at T0. A questionnaire on lifestyle characteristics was filled in. RESULTS: IgG optical density (OD) ratio at T1 was lower in the overweight-obese group regardless of COVID-19 disease positive history [p = 0.028 for the seronegative group, p = 0.032 for the seropositive group]. Neutralizing AB were lower in overweight-obese participants in the seronegative group at T1 [p = 0.008]. HDL, fasting glucose/insulin ratio (FGIR), C-reactive protein (CRP), HBA1c, uric acid, and smoke exposure were significantly correlated with BMI [p = 0.006, p \&lt; 0.001, p \&lt; 0.001, p = 0.006, p = 0.009, p \&lt; 0.001, respectively]. The main biochemical parameters that were inversely correlated with IgG and neutralizing AB titers at T1 were uric acid [p = 0.018, p = 0.002], FGIR [p = 0.001, p = 0.008] and HBA1C [p = 0.027, p = 0.038], while smoke exposure negatively affected the humoral immune responses at T0 in the convalescent group [p = 0.004, p = 0.005]. CONCLUSIONS: Current data suggests that uric acid, insulin resistance (IR), and smoke exposure could adversely affect the immune responses in overweight-obese vaccinated children, highlighting the need for actions to enhance the protection of this particular subgroup.},
	keywords = {BMI, design of the study, humoral immunity, in, in the collection, analyses, or interpretation of data, Insulin Resistance, mRNA vaccine, Obesity, or in the decision to publish the results., the writing of the manuscript, Uric Acid},
	isbn = {2079-9721 (Print)2079-9721 (Electronic)2079-9721 (Linking)},
	author = {Damianaki, A. and Marmarinos, A. and Avgeris, M. and Gourgiotis, D. and Vlachopapadopoulou, E. A. and Charakida, M. and Tsolia, M. and Kossiva, L.}
}
