@article {44697,
	title = {First trimester maternal plasma proteomic changes predictive of spontaneous moderate/late preterm delivery},
	journal = {J Matern Fetal Neonatal Med},
	volume = {36},
	number = {2},
	year = {2023},
	note = {Mavreli, DanaiTheodora, MarianaLambrou, GeorgeAvgeris, MargaritisPapantoniou, NikolasTreager-Synodinos, JanDaskalakis, GeorgeKolialexi, AggelikiengEngland2023/07/10 06:42J Matern Fetal Neonatal Med. 2023 Dec;36(2):2232074. doi: 10.1080/14767058.2023.2232074.},
	month = {Dec},
	pages = {2232074},
	abstract = {OBJECTIVE: Identification of differentially expressed proteins (DEPs) in first trimester maternal plasma between pregnant women with a subsequent spontaneous moderate/late Preterm Delivery (sPTD) and women who delivered at term. The sPTD group consisted of women who delivered between 32 degrees (/7) and 36(6/7 )weeks of gestation. METHODS: Isobaric tags for relative and absolute quantification (iTRAQ) coupled with LC-MS/MS was used for the analysis of five first trimester maternal plasma samples obtained from women with a subsequent moderate/late preterm sPTD and five women with term deliveries. Enzyme-linked immunosorbent assay (ELISA) was further applied in an independent cohort of 29 sPTD cases and 29 controls to verify the expression levels of selected proteins. RESULTS: 236 DEPs, mainly linked to coagulation and complement cascade, were identified in first trimester maternal plasma obtained from the sPTD group. Decreased levels of selected proteins, namely, VCAM-1, SAA, and Talin-1, were further confirmed using ELISA, highlighting their potential as candidate predictive biomarkers for sPTD at32 degrees (/7) and 36(6/7 )weeks of gestation. CONCLUSION: First trimester maternal plasma proteomic analysis revealed protein changes associated with subsequent moderate/late preterm sPTD.},
	keywords = {*Premature Birth, Biomarkers, Chromatography, Liquid, early prediction, Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Trimester, First, Preterm delivery (PTD), Proteomics, spontaneous preterm delivery (sPTD), tandem mass spectrometry},
	isbn = {1476-4954 (Electronic)1476-4954 (Linking)},
	author = {Mavreli, D. and Theodora, M. and Lambrou, G. and Avgeris, M. and Papantoniou, N and Treager-Synodinos, J. and Daskalakis, G. and Kolialexi, A.}
}
