@article {44706,
	title = {First Trimester Maternal Plasma Aberrant miRNA Expression Associated with Spontaneous Preterm Birth},
	journal = {Int J Mol Sci},
	volume = {23},
	number = {23},
	year = {2022},
	note = {Mavreli, DanaiTheodora, MarianaAvgeris, MargaritisPapantoniou, NikolasAntsaklis, PanagiotisDaskalakis, GeorgeKolialexi, AggelikiengSwitzerland2022/12/12 06:00Int J Mol Sci. 2022 Nov 29;23(23):14972. doi: 10.3390/ijms232314972.},
	month = {Nov 29},
	abstract = {Spontaneous Preterm Delivery (sPTD) is one of the leading causes of perinatal mortality and morbidity worldwide. The present case-control study aims to detect miRNAs differentially expressed in the first trimester maternal plasma with the view to identify predictive biomarkers for sPTD, between 320/7 and 366/7 weeks, that will allow for timely interventions for this serious pregnancy complication. Small RNA sequencing (small RNA-seq) of five samples from women with a subsequent sPTD and their matched controls revealed significant down-regulation of miR-23b-5p and miR-125a-3p in sPTD cases compared to controls, whereas miR-4732-5p was significantly overexpressed. Results were confirmed by qRT-PCR in an independent cohort of 29 sPTD cases and 29 controls. Statistical analysis demonstrated that miR-125a is a promising early predictor for sPTL (AUC: 0.895; 95\% CI: 0.814-0.972; p \&lt; 0.001), independent of the confounding factors tested, providing a useful basis for the development of a novel non-invasive predictive test to assist clinicians in estimating patient-specific risk.},
	keywords = {*MicroRNAs/metabolism, *Premature Birth/genetics, Biomarkers, Female, Humans, Infant, Newborn, microRNAs, miR-125a-5p, miR-23b-5p, miR-4732-5p, miRNAs, Pregnancy, Pregnancy Trimester, First, Sequence Analysis, RNA, small RNA sequencing, Small RNA-seq, sPTD},
	isbn = {1422-0067 (Electronic)1422-0067 (Linking)},
	author = {Mavreli, D. and Theodora, M. and Avgeris, M. and Papantoniou, N and Antsaklis, P. and Daskalakis, G. and Kolialexi, A.}
}
