@article {44708,
	title = {SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions},
	journal = {Sci Total Environ},
	volume = {804},
	year = {2022},
	note = {Galani, AikateriniAalizadeh, RezaKostakis, MariosMarkou, AthinaAlygizakis, NikiforosLytras, TheodoreAdamopoulos, Panagiotis GPeccia, JordanThompson, David CKontou, AikateriniKaragiannidis, ApostolosLianidou, Evi SAvgeris, MargaritisParaskevis, DimitriosTsiodras, SotiriosScorilas, AndreasVasiliou, VasilisDimopoulos, Meletios-AthanasiosThomaidis, Nikolaos SengUL1 TR001863/TR/NCATS NIH HHS/Netherlands2021/10/09 06:00Sci Total Environ. 2022 Jan 15;804:150151. doi: 10.1016/j.scitotenv.2021.150151. Epub 2021 Sep 7.},
	month = {Jan 15},
	pages = {150151},
	abstract = {We measured SARS-CoV-2 RNA load in raw wastewater in Attica, Greece, by RT-qPCR for the environmental surveillance of COVID-19 for 6 months. The lag between RNA load and pandemic indicators (COVID-19 hospital and intensive care unit (ICU) admissions) was calculated using a grid search. Our results showed that RNA load in raw wastewater is a leading indicator of positive COVID-19 cases, new hospitalization and admission into ICUs by 5, 8 and 9 days, respectively. Modelling techniques based on distributed/fixed lag modelling, linear regression and artificial neural networks were utilized to build relationships between SARS-CoV-2 RNA load in wastewater and pandemic health indicators. SARS-CoV-2 mutation analysis in wastewater during the third pandemic wave revealed that the alpha-variant was dominant. Our results demonstrate that clinical and environmental surveillance data can be combined to create robust models to study the on-going COVID-19 infection dynamics and provide an early warning for increased hospital admissions.},
	keywords = {(Case Number: 231-0004089064) and on March 22, 2021 to the Patent Cooperation, *Covid-19, *SARS-CoV-2, Andreas Scorilas, Margaritis Avgeris, Panagiotis G. Adamopoulos and Nikolaos S., competing interests., Covid-19, Detection and mutational analysis of an RNA virus in an environmental sample, Hospital admission rates, Hospitalization, Humans, ICU admission rates, Intensive Care Units, Method validation, RNA, Viral, RT-qPCR, Thomaidis on February 11, 2021 to the Hellenic Industrial Property Organisation, Treaty (PCT application number: PCT/EP2021/057316). All other authors declare no, Wastewater, Wastewater-Based Epidemiological Monitoring, wastewater-based epidemiology, were filed by the National and Kapodistrian University of Athens, and the authors},
	isbn = {1879-1026 (Electronic)0048-9697 (Print)0048-9697 (Linking)},
	author = {Galani, A. and Aalizadeh, R. and Kostakis, M. and Markou,A. and Alygizakis, N. and Lytras, T. and Adamopoulos, P.G. and Peccia, J. and Thompson, D. C. and Kontou, A. and Karagiannidis, A. and Lianidou,E.S. and Avgeris, M. and Paraskevis, D and Tsiodras,S. and Scorilas, A. and Vasiliou, V. and Dimopoulos, M.A. and Thomaidis, N.S.}
}
