@article {44712,
	title = {A Molecular Signature of Circulating MicroRNA Can Predict Osteolytic Bone Disease in Multiple Myeloma},
	journal = {Cancers},
	volume = {13},
	number = {15},
	year = {2021},
	note = {Papanota, Aristea-MariaTsiakanikas, PanagiotisKontos, Christos KMalandrakis, PanagiotisLiacos, Christine-IvyNtanasis-Stathopoulos, IoannisKanellias, NikolaosGavriatopoulou, MariaKastritis, EfstathiosAvgeris, MargaritisDimopoulos, Meletios-AthanasiosScorilas, AndreasTerpos, EvangelosengMIS: 5047940/European Union and Greek national funds/Switzerland2021/08/08 06:00Cancers (Basel). 2021 Jul 31;13(15):3877. doi: 10.3390/cancers13153877.},
	month = {Jul 31},
	abstract = {BACKGROUND: Multiple myeloma bone disease (MMBD) constitutes a common and severe complication of multiple myeloma (MM), impacting the quality of life and survival. We evaluated the clinical value of a panel of 19 miRNAs associated with osteoporosis in MMBD. METHODS: miRNAs were isolated from the plasma of 62 newly diagnosed MM patients with or without MMBD. First-strand cDNA was synthesized, and relative quantification was performed using qPCR. Lastly, we carried out extensive biostatistical analysis. RESULTS: Circulating levels of let-7b-5p, miR-143-3p, miR-17-5p, miR-214-3p, and miR-335-5p were significantly higher in the blood plasma of MM patients with MMBD compared to those without. Receiver operating characteristic curve and logistic regression analyses showed that these miRNAs could accurately predict MMBD. Furthermore, a standalone multi-miRNA-based logistic regression model exhibited the best predictive potential regarding MMBD. Two of those miRNAs also have a prognostic role in MM since survival analysis indicated that lower circulating levels of both let-7b-5p and miR-335-5p were associated with significantly worse progression-free survival, independently of the established prognostic factors. CONCLUSIONS: Our study proposes a miRNA signature to facilitate MMBD diagnosis, especially in ambiguous cases. Moreover, we provide evidence of the prognostic role of let-7b-5p and miR-335-5p as non-invasive prognostic biomarkers in MM.},
	keywords = {blood plasma, circulating miRNA, design of the study, in the collection, analyses, or interpretation of data, hematological malignancies, in, MMBD diagnosis, molecular biomarker, multiparametric model, Osteolysis, Prognosis, qPCR, skeletal-related events, the writing of the manuscript, or in the decision to publish the results.},
	isbn = {2072-6694 (Print)2072-6694 (Electronic)2072-6694 (Linking)},
	author = {Papanota, A. M. and Tsiakanikas, P. and Kontos, C.K. and Malandrakis, P. and Liacos, C. I. and Ntanasis-Stathopoulos, I. and Kanellias, N. and Gavriatopoulou, M. and Kastritis, E. and Avgeris, M. and Dimopoulos, M.A. and Scorilas, A. and Terpos, E.}
}
