@article {44720,
	title = {miR-181a overexpression predicts the poor treatment response and early-progression of serous ovarian cancer patients},
	journal = {International Journal of Cancer},
	volume = {147},
	number = {12},
	year = {2020},
	note = {Panoutsopoulou, KonstantinaAvgeris, MargaritisMagkou, ParaskeviMavridis, KonstantinosDreyer, TobiasDorn, JuliaObermayr, EvaReinthaller, AlexanderMichaelidou, KleitaMahner, SvenVergote, IgnaceLoverix, LiseloreBraicu, IoanaSehouli, JalidZeillinger, RobertMagdolen, ViktorScorilas, AndreasengResearch Support, Non-U.S. Gov{\textquoteright}t2020/07/06 06:00Int J Cancer. 2020 Dec 15;147(12):3560-3573. doi: 10.1002/ijc.33182. Epub 2020 Aug 1.},
	month = {Dec 15},
	pages = {3560-3573},
	abstract = {Ovarian cancer (OC) remains a leading cause of gynecological cancer-related death worldwide, characterized by poor 5-year survival. Molecular markers could serve as crucial tools of personalized prognosis and therapy. Herein, we present miR-181a as novel predictor of OC prognosis, using five independent OC cohorts. In particular, a screening (n = 81) and an institutionally independent validation (n = 100, OVCAD multicenter study) serous OC (SOC) cohorts were analyzed. Bagnoli et al (2016) OC179 (n = 124) to OC133 (n = 100) and TCGA (n = 489) served as external validation cohorts. Patients{\textquoteright} survival and disease progression were assessed as clinical endpoint events. Bootstrap analysis was performed for internal validation and decision curve analysis was utilized to evaluate clinical benefit. miR-181a overexpression was unveiled as powerful and independent molecular predictor of patients{\textquoteright} poor survival and higher risk for disease progression after debulking surgery and platinum-based chemotherapy. Analysis of the OVCAD institutionally independent cohort, as well as of Bagnoli et al. and TCGA external cohorts further confirmed the unfavorable prognostic nature of miR-181a overexpression in SOC. Strikingly, multivariate prognostic models incorporating miR-181a with established disease markers clearly improved patients{\textquoteright} risk-stratification and offered superior clinical benefit in OC prognostication. Conclusively, miR-181a evaluation could augment prognostic accuracy and support precision medicine decisions in OC.},
	keywords = {*Up-Regulation, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor/*genetics, Cohort Studies, Cystadenocarcinoma, Serous/genetics/*therapy, Cytoreduction Surgical Procedures, Disease Progression, Epithelial ovarian cancer, Female, gene expression profiling, Gene Expression Regulation, Neoplastic, Humans, microRNA-181a, MicroRNAs/*genetics, Middle Aged, Molecular diagnostics, noncoding RNA, Ovarian Neoplasms/genetics/*therapy, ovarian tumors, Platinum/*therapeutic use, Prognosis, Survival Analysis, Treatment Outcome},
	isbn = {1097-0215 (Electronic)0020-7136 (Linking)},
	author = {Panoutsopoulou, K. and Avgeris, M. and Magkou, P. and Mavridis, K. and Dreyer, T. and Dorn, J. and Obermayr, E. and Reinthaller, A. and Michaelidou, K. and Mahner, S. and Vergote, I. and Loverix, L. and Braicu, I. and Sehouli, J. and Zeillinger, R. and Magdolen, V. and Scorilas, A.}
}
