<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Panoutsopoulou, K.</style></author><author><style face="normal" font="default" size="100%">Avgeris, M.</style></author><author><style face="normal" font="default" size="100%">Magkou, P.</style></author><author><style face="normal" font="default" size="100%">Mavridis, K.</style></author><author><style face="normal" font="default" size="100%">Dreyer, T.</style></author><author><style face="normal" font="default" size="100%">Dorn, J.</style></author><author><style face="normal" font="default" size="100%">Obermayr, E.</style></author><author><style face="normal" font="default" size="100%">Reinthaller, A.</style></author><author><style face="normal" font="default" size="100%">Michaelidou, K.</style></author><author><style face="normal" font="default" size="100%">Mahner, S.</style></author><author><style face="normal" font="default" size="100%">Vergote, I.</style></author><author><style face="normal" font="default" size="100%">Loverix, L.</style></author><author><style face="normal" font="default" size="100%">Braicu, I.</style></author><author><style face="normal" font="default" size="100%">Sehouli, J.</style></author><author><style face="normal" font="default" size="100%">Zeillinger, R.</style></author><author><style face="normal" font="default" size="100%">Magdolen, V.</style></author><author><style face="normal" font="default" size="100%">Scorilas, A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">miR-181a overexpression predicts the poor treatment response and early-progression of serous ovarian cancer patients</style></title><secondary-title><style face="normal" font="default" size="100%">International Journal of Cancer</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Up-Regulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged, 80 and over</style></keyword><keyword><style  face="normal" font="default" size="100%">Biomarkers, Tumor/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Cohort Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Cystadenocarcinoma, Serous/genetics/*therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytoreduction Surgical Procedures</style></keyword><keyword><style  face="normal" font="default" size="100%">Disease Progression</style></keyword><keyword><style  face="normal" font="default" size="100%">Epithelial ovarian cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">gene expression profiling</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Regulation, Neoplastic</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">microRNA-181a</style></keyword><keyword><style  face="normal" font="default" size="100%">MicroRNAs/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular diagnostics</style></keyword><keyword><style  face="normal" font="default" size="100%">noncoding RNA</style></keyword><keyword><style  face="normal" font="default" size="100%">Ovarian Neoplasms/genetics/*therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">ovarian tumors</style></keyword><keyword><style  face="normal" font="default" size="100%">Platinum/*therapeutic use</style></keyword><keyword><style  face="normal" font="default" size="100%">Prognosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Survival Analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Treatment Outcome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Dec 15</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">12</style></number><volume><style face="normal" font="default" size="100%">147</style></volume><pages><style face="normal" font="default" size="100%">3560-3573</style></pages><isbn><style face="normal" font="default" size="100%">1097-0215 (Electronic)0020-7136 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Ovarian cancer (OC) remains a leading cause of gynecological cancer-related death worldwide, characterized by poor 5-year survival. Molecular markers could serve as crucial tools of personalized prognosis and therapy. Herein, we present miR-181a as novel predictor of OC prognosis, using five independent OC cohorts. In particular, a screening (n = 81) and an institutionally independent validation (n = 100, OVCAD multicenter study) serous OC (SOC) cohorts were analyzed. Bagnoli et al (2016) OC179 (n = 124) to OC133 (n = 100) and TCGA (n = 489) served as external validation cohorts. Patients' survival and disease progression were assessed as clinical endpoint events. Bootstrap analysis was performed for internal validation and decision curve analysis was utilized to evaluate clinical benefit. miR-181a overexpression was unveiled as powerful and independent molecular predictor of patients' poor survival and higher risk for disease progression after debulking surgery and platinum-based chemotherapy. Analysis of the OVCAD institutionally independent cohort, as well as of Bagnoli et al. and TCGA external cohorts further confirmed the unfavorable prognostic nature of miR-181a overexpression in SOC. Strikingly, multivariate prognostic models incorporating miR-181a with established disease markers clearly improved patients' risk-stratification and offered superior clinical benefit in OC prognostication. Conclusively, miR-181a evaluation could augment prognostic accuracy and support precision medicine decisions in OC.</style></abstract><accession-num><style face="normal" font="default" size="100%">32621752</style></accession-num><notes><style face="normal" font="default" size="100%">Panoutsopoulou, KonstantinaAvgeris, MargaritisMagkou, ParaskeviMavridis, KonstantinosDreyer, TobiasDorn, JuliaObermayr, EvaReinthaller, AlexanderMichaelidou, KleitaMahner, SvenVergote, IgnaceLoverix, LiseloreBraicu, IoanaSehouli, JalidZeillinger, RobertMagdolen, ViktorScorilas, AndreasengResearch Support, Non-U.S. Gov't2020/07/06 06:00Int J Cancer. 2020 Dec 15;147(12):3560-3573. doi: 10.1002/ijc.33182. Epub 2020 Aug 1.</style></notes><auth-address><style face="normal" font="default" size="100%">Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.Clinical Research Unit, Department of Obstetrics and Gynecology, School of Medicine, Technical University of Munich, Munich, Germany.Molecular Oncology Group, Department of Obstetrics and Gynecology, Comprehensive Cancer Center-Gynecologic Cancer Unit, Medical University of Vienna, Vienna, Austria.Department of Gynecology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.Department of Gynecologic Oncology, Leuven Cancer Institute, University Hospitals Leuven, KU Leuven, Leuven, Belgium.Department of Gynecology, Charite University Medicine, Campus Virchow, Berlin, Germany.</style></auth-address></record></records></xml>