<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tokas, T.</style></author><author><style face="normal" font="default" size="100%">Avgeris, M.</style></author><author><style face="normal" font="default" size="100%">Alamanis, C.</style></author><author><style face="normal" font="default" size="100%">Scorilas, A.</style></author><author><style face="normal" font="default" size="100%">Stravodimos, K. G.</style></author><author><style face="normal" font="default" size="100%">Constantinides, C.A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Downregulated KLK13 expression in bladder cancer highlights tumor aggressiveness and unfavorable patients' prognosis</style></title><secondary-title><style face="normal" font="default" size="100%">J Cancer Res Clin Oncol</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Prognosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Biomarkers, Tumor/biosynthesis/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">bladder tumors</style></keyword><keyword><style  face="normal" font="default" size="100%">Disease-Free Survival</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Regulation, Neoplastic</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Kallikrein 13</style></keyword><keyword><style  face="normal" font="default" size="100%">Kallikrein-related peptidase 13</style></keyword><keyword><style  face="normal" font="default" size="100%">Kallikrein-related peptidases</style></keyword><keyword><style  face="normal" font="default" size="100%">Kallikreins/*biosynthesis/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaplan-Meier Estimate</style></keyword><keyword><style  face="normal" font="default" size="100%">Klk</style></keyword><keyword><style  face="normal" font="default" size="100%">KLKs</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Neoplasm Invasiveness/*genetics/pathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Neoplasm Recurrence, Local/*genetics/pathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Neoplasm Staging</style></keyword><keyword><style  face="normal" font="default" size="100%">RNA, Messenger/biosynthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Urinary Bladder Neoplasms/*diagnosis/genetics/pathology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Mar</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">3</style></number><volume><style face="normal" font="default" size="100%">143</style></volume><pages><style face="normal" font="default" size="100%">521-532</style></pages><isbn><style face="normal" font="default" size="100%">1432-1335 (Electronic)0171-5216 (Print)0171-5216 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">PURPOSE: Despite recent research advantages on the molecular and subcellular background, bladder cancer (BlCa) remains a clinically neglected malignancy. This is strongly reflected by the generic approach of disease diagnosis and management. Additionally, patients' prognosis became a rather demanding task due to the great disease heterogeneity. Here, we aimed to evaluate, for the first time, the clinical value of KLK13 in BlCa. METHODS: A total of 279 bladder specimens (137 tumors, 107 adjacent normal tissues and 35 healthy samples) were included. Total RNA was extracted, reverse transcribed, and KLK13 expression was assessed by quantitative real-time PCR. RESULTS: KLK13 expression is significantly increased in bladder tumors compared to normal adjacent epithelium. However, reduced KLK13 expression is correlated with disease aggressiveness, including higher tumor stage and grade, and high-risk TaT1 tumors according to the EORTC stratification. Moreover, Kaplan-Meier and Cox regression analysis highlighted the prognostic value of the reduced KLK13 expression for the prediction of TaT1 patients' recurrence and shorter disease-free survival following TURBT. Finally, the combination of KLK13 expression with EORTC-risk stratification results to an improved prediction of TaT1 patients' outcome. CONCLUSION: This first clinical study of KLK13 in BlCa reveals its deregulated expression in bladder tumors and highlights KLK13 as a promising marker for improving TaT1 patients' prognosis following treatment.</style></abstract><accession-num><style face="normal" font="default" size="100%">27858162</style></accession-num><notes><style face="normal" font="default" size="100%">Tokas, TheodorosAvgeris, MargaritisAlamanis, ChristosScorilas, AndreasStravodimos, Konstantinos GConstantinides, Constantinos AengGermany2016/11/20 06:00J Cancer Res Clin Oncol. 2017 Mar;143(3):521-532. doi: 10.1007/s00432-016-2301-6. Epub 2016 Nov 17.</style></notes><custom2><style face="normal" font="default" size="100%">PMC11819349</style></custom2><auth-address><style face="normal" font="default" size="100%">First Department of Urology, &quot;Laiko&quot; General Hospital, Medical School, University of Athens, Agiou Thoma 17, 11527, Athens, Greece. ttokas@yahoo.com.Department of Urology and Andrology, General Hospital Hall in Tirol, Milser Str. 10, 6060, Hall in Tirol, Austria. ttokas@yahoo.com.Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, 15701, Athens, Greece.First Department of Urology, &quot;Laiko&quot; General Hospital, Medical School, University of Athens, Agiou Thoma 17, 11527, Athens, Greece.</style></auth-address></record></records></xml>