@article {7042, title = {When to recommend a second autograft in patients with relapsed myeloma?}, journal = {Leukemia and Lymphoma}, volume = {58}, year = {2017}, note = {Export Date: 18 February 2017References: Child, J.A., Morgan, G.J., Davies, F.E., High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma (2003) N Engl J Med, 348, pp. 1875-1883;Bjorkstrand, B., Gahrton, G., High-dose treatment with autologous stem cell transplantation in multiple myeloma: past, present, and future (2007) Semin Hematol, 44, pp. 227-233; McElwain, T.J., Powles, R.L., High-dose intravenous melphalan for plasma-cell leukaemia and myeloma (1983) Lancet, 2, pp. 822-824; Harousseau, J.L., Attal, M., Divine, M., Autologous stem cell transplantation after first remission induction treatment in multiple myeloma: a report of the French Registry on autologous transplantation in multiple myeloma (1995) Blood, 85, pp. 3077-3085; Attal, M., Harousseau, J.L., Stoppa, A.M., A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma (1996) N Engl J Med, 335, pp. 91-97; McCarthy, P.L., Owzar, K., Hofmeister, C.C., Lenalidomide after stem-cell transplantation for multiple myeloma (2012) N Engl J Med, 366, pp. 1770-1781; Attal, M., Lauwers-Cances, V., Marit, G., Lenalidomide maintenance after stem-cell transplantation for multiple myeloma (2012) N Engl J Med, 366, pp. 1782-1791; San-Miguel, J.F., Mateos, M.V., Can multiple myeloma become a curable disease? 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(1998) Bone Marrow Transplant, 21, pp. 887-892 }, month = {2017}, pages = {781 - 787}, abstract = {In the current evolving landscape of myeloma therapies, no recommended salvage strategy exists for patients with relapsed multiple myeloma (MM) after initial successful autologous stem cell transplantation (ASCT) and therapeutic options extend from conventional chemotherapy and novel agents to second autologous and allogeneic transplants. In this article, we summarize the documented evidence about the utilization of second ASCT in patients with relapsed MM after a primary auto-graft and discuss the correct timing for such a salvage approach, the individual characteristics of patients who will benefit more, as well as the therapeutic role of second ASCT in the modern era of forthcoming anti-myeloma treatments. {\textcopyright} 2016 Informa UK Limited, trading as Taylor \& Francis Group.}, keywords = {multiple myeloma, relapse, Second ASCT}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84999810220\&doi=10.1080\%2f10428194.2016.1246729\&partnerID=40\&md5=4d4675f6b9428398c6e5fdafa5dc0c3c}, author = {Ziogas, D.C. and Terpos, E. and Dimopoulos, M.A.} }