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The mechanisms that DNA damage could confer to the mutational load and the formation of neoantigens and how this could be exploited to advance our immunotherapeutic strategies is discussed in this review. {\textcopyright} Annals of Translational Medicine.}, keywords = {Cancer, DNA damage, Immunotherapy, Mutational load}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85006217731\&doi=10.21037\%2fatm.2016.07.11\&partnerID=40\&md5=86227c302227beb320bd1806c114bb15}, author = {Liontos, M. and Anastasiou, I. and Bamias, A. and Dimopoulos, M.-A.} }