@article {7452,
	title = {Two cycles of adjuvant carboplatin in stage I seminoma: 8-year experience by the Hellenic Cooperative Oncology Group (HECOG)},
	journal = {World Journal of Urology},
	volume = {34},
	year = {2016},
	note = {Cited By :1Export Date: 21 February 2017},
	month = {2016},
	pages = {853 - 857},
	abstract = {Purpose: Following the establishment of adjuvant carboplatin in stage I testicular seminoma as a standard, we adopted this treatment for all stage I seminoma patients. We report our 8-year experience and compare these results with our previous adjuvant etoposide/cisplatin (EP) strategy. Patients and methods: Patients with stage I seminoma, treated with adjuvant carboplatin and with a minimum follow-up of 1~year, were included. Two cycles of carboplatin [area under the curve (AUC) 6] were administered. Results: A total of 138 patients with median age of 34~years, treated from September 2003 to December 2011, were selected. There were 5 relapses [5-year relapse-free rate (RFR) 96.8~\% (95~\% confidence interval 91.6{\textendash}98.8)]: 3 relapses at retroperitoneal lymph nodes, 1 relapse at the adrenal~gland, and 1 isolated brain metastasis. Four patients with relapse were cured with salvage chemotherapy. All patients with relapse had tumor diameter >=4~cm and/or age <=34~years. Patients with at least 1 of the above risk factors (n~=~111) had a significantly higher relapse rate compared with a similar population (n~=~64) treated with 2 cycles of adjuvant EP: 5-year RFR was 95~\% (SE 2~\%) versus 100~\% (SE 0~\%), (p~=~0.067). Conclusions: Age and tumor diameter were associated with relapse in stage I seminoma treated with adjuvant carboplatin. Although adjuvant carboplatin in patients with age <=34 and/or tumor diameter >=4~cm is associated with higher relapse rates than EP, the prognosis of these patients is excellent, and therefore, the use of less toxic treatment is justified. {\textcopyright} 2015, Springer-Verlag Berlin Heidelberg.},
	keywords = {Seminoma, Stage I, Two cycles of carboplatin},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944581151\&doi=10.1007\%2fs00345-015-1695-0\&partnerID=40\&md5=05dda24fe8888f8e7310cb827c29b79a},
	author = {Koutsoukos, K. and Tzannis, K. and Christodoulou, C. and Karavasilis, V. and Bakoyiannis, C and Makatsoris, T. and Papandreou, C.N. and Pectasides, D. and Dimopoulos, M.A. and Bamias, A.}
}
