@article {7476,
	title = {Glomerular expression of matrix metalloproteinases in AL-amyloidosis and association with renal function at the time of kidney biopsy},
	journal = {Clinical Nephrology},
	volume = {85},
	year = {2016},
	note = {Export Date: 21 February 2017},
	month = {2016},
	pages = {44 - 52},
	abstract = {Background: Matrix metalloproteinases (MMPs) have been implicated in the pathophysiology of various renal diseases, however, there are limited data regarding their role in renal AL-amyloidosis. In the present study, we evaluated the glomerular expression of MMPs in renal-biopsy specimens containing AL-amyloid deposits. We also examined the association of MMPs with renal function at the time of diagnostic renal biopsy. Methods: We performed immunohistochemistry with monoclonal antibodies against MMP-1, MMP-2, MMP-3, MMP-9, and TIMP-1 in 19 kidney-biopsy specimens with AL-amyloidosis and 8 specimens from normal kidney tissue. We used clinical data of the patients at the time of kidney biopsy to evaluate the association between MMP expression and renal function. Results: We found increased MMP-1 and MMP-3 expression within the amyloid deposits and adjacent tissues in > 50\% of the amyloid-positive biopsies, whereas MMP-1 and MMP-3 were negative in control samples. In contrast, we found no significant glomerular MMP-2 and TIMP-1 expression in amyloid-containing or normal kidneys. MMP-9 expression was found in the glomerular basement membrane equally in AL-amyloidosis and control specimens. The presence of MMP-1 and MMP-3 in the glomeruli of patients with AL-amyloidosis correlated with worse renal function at the time of kidney biopsy. Conclusion: The findings of this study show increased glomerular expression of MMP-1 and MMP-3 in patients with AL-amyloidosis which is associated with worse renal function at the time of the kidney biopsy. Our results suggest an important role for MMP-1 and MMP-3 in the pathogenesis of renal damage in AL-amyloidosis. {\textcopyright} 2016 Dustri-Verlag Dr. K. Feistle.},
	keywords = {AL-amyloidosis, Matrix metalloproteinases, Renal amyloidosis},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957868657\&doi=10.5414\%2fCN108670\&partnerID=40\&md5=331e35ae747135fb56c4d8c30f3019af},
	author = {Charitaki, E. and Kastritis, E. and Petraki, C. and Liapis, K. and Adamidis, K. and Apostolou, T. and Christodoulidou, C. and Nikolopoulou, N. and Terpos, E. and Nakopoulou, L. and Dimopoulos, M.A.}
}
