@article {7557,
	title = {Low protein expression of MET in ER-positive and HER2-positive breast cancer},
	journal = {Anticancer Research},
	volume = {34},
	year = {2014},
	note = {Cited By :3Export Date: 21 February 2017},
	month = {2014},
	pages = {1227 - 1231},
	abstract = {Aim: The mesenchymal-epithelial transition factor (MET) is a receptor tyrosine kinase that plays a key role in cell survival, growth, angiogenesis and metastasis. Because its expression is frequently altered in tumors, MET is currently under investigation as a potential target for anticancer therapy. The purpose of the present study was to determine the prognostic value of tumor MET expression levels in patients with estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-positive breast cancer, in order to strengthen the rationale for targeted therapy using MET inhibitors in this breast cancer subpopulation. Materials and Methods: We determined the expression of MET in formalin-fixed paraffin-embedded surgical specimens of ERand HER2-positive breast cancer by immunohistochemistry. Results: Comparisons of MET expression with clinical parameters, including survival of the patients, were performed with MET expression as a dichotomized variable classified as high or low. Out of 78 tumors, 3 (3.8\%) showed high MET expression. The analysis examining the association between MET and survival did not yield any statistically significant result regarding overall survival or disease-free survival. Conclusion: ER- and HER2-positive breast carcinomas do not exhibit high MET expression. This null finding, the first to be reported in the literature, is of great importance, since it indicates that this sub-group population is not proper candidate for clinical trials with MET inhibitors.},
	keywords = {Biomarkers, breast cancer, ER-positive, HER2- positive, MET, Prognosis},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899675373\&partnerID=40\&md5=20aacd5e57a69e8b434e19bd036c7390},
	author = {Zagouri, F. and Brandstetter, A. and Moussiolis, D. and Chrysikos, D. and Dimitrakakis, C. and Tsigginou, A. and Marinopoulos, S. and Zografos, G.C. and Sergentanis, T.N. and Dimopoulos, M.-A. and Filipits, M.}
}
