@article {7573,
	title = {Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer},
	journal = {Carcinogenesis},
	volume = {35},
	year = {2014},
	note = {Cited By :41Export Date: 21 February 2017},
	month = {2014},
	pages = {1012 - 1019},
	abstract = {Triple-negative (TN) breast cancer is an aggressive subtype of breast cancer associated with a unique set of epidemiologic and genetic risk factors. We conducted a two-stage genome-wide association study of TN breast cancer (stage 1: 1529 TN cases, 3399 controls; stage 2: 2148 cases, 1309 controls) to identify loci that influence TN breast cancer risk. Variants in the 19p13.1 and PTHLH loci showed genome-wide significant associations (P \&lt; 5 {\texttimes} 10-8) in stage 1 and 2 combined. Results also suggested a substantial enrichment of significantly associated variants among the single nucleotide polymorphisms (SNPs) analyzed in stage 2. Variants from 25 of 74 known breast cancer susceptibility loci were also associated with risk of TN breast cancer (P \&lt; 0.05). Associations with TN breast cancer were confirmed for 10 loci (LGR6, MDM4, CASP8, 2q35, 2p24.1, TERT-rs10069690, ESR1, TOX3, 19p13.1, RALY), and we identified associations with TN breast cancer for 15 additional breast cancer loci (P \&lt; 0.05: PEX14, 2q24.1, 2q31.1, ADAM29, EBF1, TCF7L2, 11q13.1, 11q24.3, 12p13.1, PTHLH, NTN4, 12q24, BRCA2, RAD51L1-rs2588809, MKL1). Further, two SNPs independent of previously reported signals in ESR1 [rs12525163 odds ratio (OR) = 1.15, P = 4.9 {\texttimes} 10-4] and 19p13.1 (rs1864112 OR = 0.84, P = 1.8 {\texttimes} 10-9) were associated with TN breast cancer. A polygenic risk score (PRS) for TN breast cancer based on known breast cancer risk variants showed a 4-fold difference in risk between the highest and lowest PRS quintiles (OR = 4.03, 95\% confidence interval 3.46-4.70, P = 4.8 {\texttimes} 10-69). This translates to an absolute risk for TN breast cancer ranging from 0.8\% to 3.4\%, suggesting that genetic variation may be used for TN breast cancer risk prediction.},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901988970\&doi=10.1093\%2fcarcin\%2fbgt404\&partnerID=40\&md5=369553ebc1738b06f845e73f4d1c4958},
	author = {Purrington, K.S. and Slager, S. and Eccles, D. and Yannoukakos, D. and Fasching, P.A. and Miron, P. and Carpenter, J. and Chang-claude, J. and Martin, N.G. and Montgomery, G.W. and Kristensen, V. and Anton-Culver, H. and Goodfellow, P. and Tapper, W.J. and Rafiq, S. and Gerty, S.M. and Durcan, L. and Konstantopoulou, I. and Fostira, F. and Vratimos, A. and Apostolou, P. and Konstanta, I. and Kotoula, V. and Lakis, S. and Dimopoulos, M.A. and Skarlos, D. and Pectasides, D. and Fountzilas, G. and Beckmann, M.W. and Hein, A. and Ruebner, M. and Ekici, A.B. and Hartmann, A. and Schulz-wendtland, R. and Renner, S.P. and Janni, W. and Rack, B. and Scholz, C. and Neugebauer, J. and Andergassen, U. and Lux, M.P. and Haeberle, L. and Clarke, C. and Pathmanathan, N. and Rudolph, A. and Flesch-janys, D. and Nickels, S. and Olson, J.E. and Ingle, J.N. and Olswold, C. and Slettedahl, S. and Eckel-passow, J.E. and Anderson, S.K. and Visscher, D.W. and Cafourek, V.L. and Sicotte, H. and Prodduturi, N. and Weiderpass, E. and Bernstein, L. and Ziogas, A. and Ivanovich, J. and Giles, G.G. and Baglietto, L. and Southey, M. and Kosma, V. and Fischer, H.-P. and Reed, M.W. and Cross, S.S. and Deming-halverson, S. and Shrubsole, M. and Cai, Q. and Shu, X. and Daly, M. and Weaver, J. and Ross, E. and Klemp, J. and Sharma, P. and Torres, D. and R{\"u}diger, T. and W{\"o}lfing, H. and Ulmer, H. and F{\"o}rsti, A. and Khoury, T. and Kumar, S. and Pilarski, R. and Shapiro, C.L. and Greco, D. and Heikkil{\"a}, P. and Aittom{\"a}ki, K. and Blomqvist, C. and Irwanto, A. and Liu, J. and Pankratz, V.S. and Wang, X. and Severi, G. and Mannermaa, A. and Easton, D. and Hall, P. and Brauch, H. and Cox, A. and Zheng, W. and Godwin, A.K. and Hamann, U. and Ambrosone, C. and Toland, A.E. and Nevanlinna, H. and Vachon, C.M. and Couch, F.J.}
}
