@article {7600,
	title = {Aromatase inhibitors with or without gonadotropin-releasing hormone analogue in metastatic male breast cancer: A case series},
	journal = {British Journal of Cancer},
	volume = {108},
	year = {2013},
	note = {Cited By :21Export Date: 21 February 2017},
	month = {2013},
	pages = {2259 - 2263},
	abstract = {Background:Data regarding the safety and effectiveness of aromatase inhibitors (AIs) as monotherapy or combined with gonadotropin-releasing hormone (GnRH) analogue in male breast cancer are scarce. Methods: In this retrospective chart review, cases of male breast cancer patients treated with AIs with or without a GnRH analogue were evaluated. Results: Twenty-three men were included into this case series. Aromatase inhibitors in combination with or without a GnRH analogue were given as first-line therapy in 60.9\% and as second-line therapy in 39.1\% of patients, respectively. All patients had visceral metastases, whereas in five of them bone lesions coexisted. In all cases AIs were tolerated well, and no case of grade 3 and 4 adverse events was reported. A partial response was observed in 26.1\% of patients and stable disease in 56.5\%. Median overall survival (OS) was 39 months and median progression-free survival (PFS) was 13 months. Regarding OS and PFS, no significant effects of GnRH analogue co-administration or type of AI were noted.Conclusion:Our study shows that AIs with or without GnRH analogues may represent an effective and safe treatment option for hormone-receptor positive, pretreated, metastatic, male breast cancer patients. {\textcopyright} 2013 Cancer Research UK. All rights reserved.},
	keywords = {Anastrazole, Aromatase inhibitors, Exemestane, Letrozole, Male breast cancer},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84884174910\&doi=10.1038\%2fbjc.2013.255\&partnerID=40\&md5=78ed1975921f30157c799a53ff772d0c},
	author = {Zagouri, F. and Sergentanis, T.N. and Koutoulidis, V. and Sparber, C. and Steger, G.G. and Dubsky, P. and Zografos, G.C. and Psaltopoulou, T. and Gnant, M. and Dimopoulos, M.-A. and Bartsch, R.}
}
