@article {7616,
	title = {Plasma cell leukemia: Consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group},
	journal = {Leukemia},
	volume = {27},
	year = {2013},
	note = {Cited By :62Export Date: 21 February 2017},
	month = {2013},
	pages = {780 - 791},
	abstract = {Plasma cell leukemia (PCL) is a rare and aggressive variant of myeloma characterized by the presence of circulating plasma cells. It is classified as either primary PCL occurring at diagnosis or as secondary PCL in patients with relapsed/refractory myeloma. Primary PCL is a distinct clinic-pathological entity with different cytogenetic and molecular findings. The clinical course is aggressive with short remissions and survival duration. The diagnosis is based upon the percentage (>=20\%) and absolute number (>=2 {\texttimes} 10 9/l) of plasma cells in the peripheral blood. It is proposed that the thresholds for diagnosis be re-examined and consensus recommendations are made for diagnosis, as well as, response and progression criteria. Induction therapy needs to begin promptly and have high clinical activity leading to rapid disease control in an effort to minimize the risk of early death. Intensive chemotherapy regimens and bortezomib-based regimens are recommended followed by high-dose therapy with autologous stem cell transplantation if feasible. Allogeneic transplantation can be considered in younger patients. Prospective multicenter studies are required to provide revised definitions and better understanding of the pathogenesis of PCL. {\textcopyright} 2013 Macmillan Publishers Limited All rights reserved.},
	keywords = {bortezomib, cytogenetics, myeloma, plasma cell leukemia, Prognosis, transplantation},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876141059\&doi=10.1038\%2fleu.2012.336\&partnerID=40\&md5=075e10db35d90c004a7007ab89e485c9},
	author = {Fern{\'a}ndez De Larrea, C. and Kyle, R.A. and Durie, B.G.M. and Ludwig, H. and Usmani, S. and Vesole, D.H. and Hajek, R. and San Miguel, J.F. and Sezer, O. and Sonneveld, P. and Kumar, S.K. and Mahindra, A. and Comenzo, R. and Palumbo, A. and Mazumber, A. and Anderson, K.C. and Richardson, P.G. and Badros, A.Z. and Caers, J. and Cavo, M. and Leleu, X. and Dimopoulos, M.A. and Chim, C.S. and Schots, R. and Noeul, A. and Fantl, D. and Mellqvist, U.-H. and Landgren, O. and Chanan-Khan, A. and Moreau, P. and Fonseca, R. and Merlini, G. and Lahuerta, J.J. and Blad{\'e}, J. and Orlowski, R.Z. and Shah, J.J.}
}
