@article {7623,
	title = {Persistent overall survival benefit and no increased risk of second malignancies with bortezomib-melphalan-prednisone versus melphalan-prednisone in patients with previously untreated multiple myeloma},
	journal = {Journal of Clinical Oncology},
	volume = {31},
	year = {2013},
	note = {Cited By :112Export Date: 21 February 2017},
	month = {2013},
	pages = {448 - 455},
	abstract = {Purpose This final analysis of the phase III VISTA trial (Velcade As Initial Standard Therapy in Multiple Myeloma: Assessment With Melphalan and Prednisone) was conducted to determine whether the overall survival (OS) benefit with bortezomib-melphalan-prednisone (VMP) versus melphalanprednisone (MP) in patients with myeloma who were ineligible for transplantation was maintained after 5 years of follow-up and to explore the risk of second primary malignancies. Patients and Methods In all, 682 patients received up to nine 6-week cycles of VMP or MP and were then observed every 12 weeks or less. Data on second primary malignancies were collected by individual patient inquiries at all sites from 655 patients. Results After median follow-up of 60.1 months (range, 0 to 74 months), there was a 31\% reduced risk of death with VMP versus MP (hazard ratio [HR], 0.695; P < .001; median OS 56.4 v 43.1 months). OS benefit with VMP was seen across prespecified patient subgroups (age >= 75 years, stage III myeloma, creatinine clearance < 60 mL/min). Sixty-three percent of VMP patients and 73\% of MP patients had received subsequent therapy. Time to next therapy (median, 30.7 v 20.5 months; HR, 0.557; P < .001) was longer with VMP than with MP. Among patients who received subsequent therapies, survival from start of subsequent therapy was similar following VMP (median, 28.1 months) or MP (median, 26.8 months; HR, 0.914). Following VMP/MP, incidence proportions of hematologic malignancies (1\%/1\%) and solid tumors (5\%/3\%) and exposure-adjusted incidence rates (0.017/0.013 per patient-year) were similar and were consistent with background rates. Conclusion VMP resulted in a significant reduction in risk of death versus MP that was maintained after 5 years{\textquoteright} follow-up and despite substantial use of novel-agent-based salvage therapies. There is no emerging safety signal for second primary malignancies following VMP. {\textcopyright} 2012 by American Society of Clinical Oncology.},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874768399\&doi=10.1200\%2fJCO.2012.41.6180\&partnerID=40\&md5=286146e73383ce7e878ce334aa2e17fc},
	author = {Miguel, J.F.S. and Schlag, R. and Khuageva, N.K. and Dimopoulos, M.A. and Shpilberg, O. and Kropff, M. and Spicka, I. and Petrucci, M.T. and Palumbo, A. and Samoilova, O.S. and Dmoszynska, A. and Abdulkadyrov, K.M. and Delforge, M. and Jiang, B. and Mateos, M.-V. and Anderson, K.C. and Esseltine, D.-L. and Liu, K. and Deraedt, W. and Cakana, A. and van de Velde, H. and Richardson, P.G.}
}
