@article {7637,
	title = {HSP90, HSPA8, HIF-1 alpha and HSP70-2 polymorphisms in breast cancer: a case-control study.},
	journal = {Molecular biology reports},
	volume = {39},
	year = {2012},
	note = {Cited By :16Export Date: 21 February 2017},
	month = {2012},
	pages = {10873 - 10879},
	abstract = {This case control study aims to investigate the role of HSP90 Gln488His (C > G), HSP70-2 P1/P2, HIF-1 alpha C1772T and HSPA8 intronic 1541-1542delGT polymorphisms as potential risk factors and/or prognostic markers for breast cancer. 113 consecutive incident cases of histologically confirmed ductal breast cancer and 124 healthy cases were recruited. The above mentioned polymorphisms were genotyped; multivariate logistic regression was performed. HSP90 GG (His/His) genotype was associated with elevated breast cancer risk. Similarly, the allele dose-response model pointed to increase in breast cancer risk per G allele. HSP70-2 P1/P2, HSPA8 intronic 1541-1542delGT and HIF-1 alpha polymorphisms were not associated with breast cancer risk, as evidenced by the dose-response allele models. The positive association between HSP90 G allele and breast cancer risk seemed to pertain to both premenopausal and postmenopausal women. With respect to survival analysis, none of the aforementioned polymorphisms was associated with either disease-free survival or overall survival. HSP90α Gln488His polymorphism seems to be a risk factor for breast cancer. On the other hand, our study did not point to excess risk conferred by HSPA8 1541-1542delGT, Hsp70-2 P1/P2 and HIF-1α C1772T.},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84875811243\&partnerID=40\&md5=db55d0f4b17ebf0a172fd64913cb2cb8},
	author = {Zagouri, F. and Sergentanis, T.N. and Gazouli, M. and Tsigginou, A. and Dimitrakakis, C. and Papaspyrou, I. and Eleutherakis-Papaiakovou, E. and Chrysikos, D. and Theodoropoulos, G. and Zografos, G.C. and Antsaklis, A. and Dimopoulos, A.M. and Papadimitriou, C.A.}
}
