@article {7641,
	title = {Increased angiogenesis and enhanced bone formation in patients with IgM monoclonal gammopathy and urticarial skin rash: New insight into the biology of Schnitzler syndrome},
	journal = {Haematologica},
	volume = {97},
	year = {2012},
	note = {Cited By :11Export Date: 21 February 2017},
	month = {2012},
	pages = {1699 - 1703},
	abstract = {Schnitzler syndrome is a rare plasma cell disorder the pathogenesis of which is still not fully understood. We evaluated the circulating levels of four major angiogenic cytokines (VEGF, angiogenin, angiopoietin-1 and angiopoietin-2) and six bone remodeling markers (sRANKL, osteoprotegerin, dickkopf-1, CTX, osteocalcin and bone-specific alkaline phosphatase-bALP) in 13 patients with Schnitzler syndrome. At diagnosis, patients had elevated angiogenic cytokines. The mean VEGF levels were almost 3.5-fold higher in Schnitzler syndrome compared to controls, while 10 of 13 patients had higher VEGF than the upper control value. Successful treatment led to a significant reduction in VEGF. Patients with Schnitzler syndrome had increased bone formation (high bALP, osteocalcin and osteoprotegerin) which was not balanced by an increase in bone resorption (normal CTX and sRANKL). These data support a role for VEGF as a new minor criterion in the diagnosis and follow up of Schnitzler syndrome, while the uncoupling of bone remodeling in favor of bone formation justifies the presence of bone densification. {\textcopyright}2012 Ferrata Storti Foundation.},
	keywords = {Angiogenesis, Bone formation, Schnitzler syndrome, VEGF},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84868568168\&doi=10.3324\%2fhaematol.2012.067306\&partnerID=40\&md5=893861d154d0fa5abcf524e0dd848d08},
	author = {Terpos, E. and Asli, B. and Christoulas, D. and Brouet, J.-C. and Kastritis, E. and Rybojad, M. and Bengoufa, D. and Dimopoulos, M.A. and Fermand, J.P.}
}
