@article {7664,
	title = {Continuous lenalidomide treatment for newly diagnosed multiple myeloma},
	journal = {New England Journal of Medicine},
	volume = {366},
	year = {2012},
	note = {Cited By :362Export Date: 21 February 2017},
	month = {2012},
	pages = {1759 - 1769},
	abstract = {BACKGROUND: Lenalidomide has tumoricidal and immunomodulatory activity against multiple myeloma. This double-blind, multicenter, randomized study compared melphalan-prednisone- lenalidomide induction followed by lenalidomide maintenance (MPR-R) with melphalan-prednisone-lenalidomide (MPR) or melphalan-prednisone (MP) followed by placebo in patients 65 years of age or older with newly diagnosed multiple myeloma. METHODS: We randomly assigned patients who were ineligible for transplantation to receive MPR-R (nine 4-week cycles of MPR followed by lenalidomide maintenance therapy until a relapse or disease progression occurred [152 patients]) or to receive MPR (153 patients) or MP (154 patients) without maintenance therapy. The primary end point was progression-free survival. RESULTS: The median follow-up period was 30 months. The median progression-free survival was significantly longer with MPR-R (31 months) than with MPR (14 months; hazard ratio, 0.49; P<0.001) or MP (13 months; hazard ratio, 0.40; P<0.001). Response rates were superior with MPR-R and MPR (77\% and 68\%, respectively, vs. 50\% with MP; P<0.001 and P = 0.002, respectively, for the comparison with MP). The progression-free survival benefit associated with MPR-R was noted in patients 65 to 75 years of age but not in those older than 75 years of age (P = 0.001 for treatment-by-age interaction). After induction therapy, a landmark analysis showed a 66\% reduction in the rate of progression with MPR-R (hazard ratio for the comparison with MPR, 0.34; P<0.001) that was age-independent. During induction therapy, the most frequent adverse events were hematologic; grade 4 neutropenia was reported in 35\%, 32\%, and 8\% of the patients in the MPR-R, MPR, and MP groups, respectively. The 3-year rate of second primary tumors was 7\% with MPR-R, 7\% with MPR, and 3\% with MP. CONCLUSIONS: MPR-R significantly prolonged progression-free survival in patients with newly diagnosed multiple myeloma who were ineligible for transplantation, with the greatest benefit observed in patients 65 to 75 years of age. (Funded by Celgene; MM-015 ClinicalTrials.gov number, NCT00405756.) Copyright {\textcopyright} 2012 Massachusetts Medical Society.},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860744403\&doi=10.1056\%2fNEJMoa1112704\&partnerID=40\&md5=92a72feb0b7f2e00b2754367622f0d69},
	author = {Palumbo, A. and Hajek, R. and Delforge, M. and Kropff, M. and Petrucci, M.T. and Catalano, J. and Gisslinger, H. and Wiktor-Jȩdrzejczak, W. and Zodelava, M. and Weisel, K. and Cascavilla, N. and Iosava, G. and Cavo, M. and Kloczko, J. and Blad{\'e}, J. and Beksac, M. and Spicka, I. and Plesner, T. and Radke, J. and Langer, C. and Yehuda, D.B. and Corso, A. and Herbein, L. and Yu, Z. and Mei, J. and Jacques, C. and Dimopoulos, M.A.}
}
