@article {7690,
	title = {Personalized therapy in multiple myeloma according to patient age and vulnerability: A report of the European Myeloma Network (EMN)},
	journal = {Blood},
	volume = {118},
	year = {2011},
	note = {Cited By :139Export Date: 21 February 2017},
	month = {2011},
	pages = {4519 - 4529},
	abstract = {Most patients with newly diagnosed multiple myeloma (MM) are aged > 65 years with 30\% aged > 75 years. Many elderly patients are also vulnerable because of comorbidities that complicate the management of MM. The prevalence of MM is expected to rise over time because of an aging population. Most elderly patients with MM are ineligible for autologous transplantation, and the standard treatment has, until recently, been melphalan plus prednisone. The introduction of novel agents, such as thalidomide, bortezomib, and lenalidomide, has improved outcomes; however, elderly patients withMM are more susceptible to side effects and are often unable to tolerate full drug doses. For these patients, lower-dose-intensity regimens improve the safety profile and thus optimize treatment outcome. Further research into the best treatment strategies for vulnerable elderly patients is urgently needed. Appropriate screening for vulnerability and an assessment of cardiac, pulmonary, renal, hepatic, and neurologic functions, as well as age > 75 years, at the start of therapy allows treatment strategies to be individualized and drug doses to be tailored to improve tolerability and optimize efficacy. Similarly, occurrence of serious nonhematologic adverse events during treatment should be carefully taken into account to adjust doses and optimize outcomes. {\textcopyright} 2011 by The American Society of Hematology.},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-80055066620\&doi=10.1182\%2fblood-2011-06-358812\&partnerID=40\&md5=43c29b54e2263075b0726a86ff65b52e},
	author = {Palumbo, A. and Bringhen, S. and Ludwig, H. and Dimopoulos, M.A. and Blad{\'e}, J. and Mateos, M.V. and Rosi{\~n}ol, L. and Boccadoro, M. and Cavo, M. and Lokhorst, H. and Zweegman, S. and Terpos, E. and Davies, F. and Driessen, C. and Gimsing, P. and Gramatzki, M. and H{\`a}jek, R. and Johnsen, H.E. and Da Costa, F.L. and Sezer, O. and Spencer, A. and Beksac, M. and Morgan, G. and Einsele, H. and San Miguel, J.F. and Sonneveld, P.}
}
