@article {7692,
	title = {Prognostic factors for early-stage epithelial ovarian cancer, treated with adjuvant carboplatin/paclitaxel chemotherapy: A single institution experience},
	journal = {Gynecologic Oncology},
	volume = {123},
	year = {2011},
	note = {Cited By :8Export Date: 21 February 2017},
	month = {2011},
	pages = {37 - 42},
	abstract = {Objective: Early-stage epithelial ovarian cancer represents a prognostically heterogenous group. We studied prognostic factors in patients treated with adjuvant paclitaxel/carboplatin chemotherapy. Methods: Data was extracted from 147 patients with FIGO stage IA/IB, grade 2/3 or stage IC/IIA (any grade) who underwent primary surgery followed by paclitaxel/carboplatin chemotherapy. Results: Median follow-up was 88 months. Ten-year relapse-free (RFS) and disease-specific survival (DSS) were: 81\% (95\% confidence interval [CI]: 73-89) and 81\% (95\% CI: 73-89). On multivariate analysis, non serous histology was associated with reduced risk for RFS (0.294, 95\% CI: 0.112-0.577, p = 0.001) and DSS (0.194, 95\% CI: 0.075-0.504, p = 0.001), while high-risk category (stage IC/IIA and grade 2/3) with increased risk for RFS (3.989, 95\% CI: 1.189-13.389, p = 0.009) and DSS (3.989, 95\% CI: 1.064-16.386, p = 0.038). The combination of histology and grade identified 3 groups with distinctly different 10-year RFS and DSS rates (p < 0.001): grade 1 (100\% and 100\%), non-serous grade 2/3 (83\% and 86\%) and serous grade 2/3 (60\% and 60\%). Conclusions: Serous histology is an adverse prognostic factor in early-stage ovarian cancer treated with adjuvant paclitaxel/carboplatin. Risk stratification according to histology and grade is a useful discriminator of prognosis and can be used in the design of future studies. {\textcopyright} 2011 Elsevier Inc. All rights reserved.},
	keywords = {Early stage, Ovarian cancer, Prognostic factors, Serous, Tumor type},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052578547\&doi=10.1016\%2fj.ygyno.2011.06.033\&partnerID=40\&md5=3268f1d63d140cdf464c86fc151b544e},
	author = {Bamias, A. and Karadimou, A. and Soupos, N. and Sotiropoulou, M. and Zagouri, F. and Haidopoulos, D. and Thomakos, N. and Rodolakis, A. and Antsaklis, A. and Dimopoulos, M.A.}
}
