@article {7728,
	title = {Time to castration resistance is an independent predictor of castration-resistant prostate cancer survival},
	journal = {Anticancer Research},
	volume = {31},
	year = {2011},
	note = {Cited By :4Export Date: 21 February 2017},
	month = {2011},
	pages = {1475 - 1482},
	abstract = {Background/Aim: Easily assessable clinical predictors of response to chemotherapy in advanced castration-resistant prostate cancer (CRPC) are few. The objective of this retrospective study was to search for and identify such candidate predictors of outcome. Patients and Methods: A retrospective analysis of clinical data of CRPC patients entered in the Clinical Therapeutics{\textquoteright} departmental prostate cancer database from 1996-2009 was performed. Univariate and multivariate analyses for progression-free survival and overall survival included patients receiving both docetaxel- and non-docetaxel-containing regimens. Results: From 1996 until June 2009, 286 out of 313 patients in our database were treated with chemotherapy. Prostate-specific antigen (PSA) reduction >30\% correlated with improved survival irrespective of treatment. Beyond previously reported predictors, i.e. baseline PSA>30 ng/dl, hemoglobin below 10 mg/dl, weight loss, poor performance status, elevated lactic dehydrogenase and alkaline phosphatase, and time to CRPC of less than or equal to two years was associated with a poor overall survival and shorter progression-free survival upon univariate analysis. Pain was associated with shorter survival. Multivariate analysis confirmed time to CRPC, lactate dehydrogenase and alkaline phosphatase as independent predictors of overall and progression-free survival. Conclusion: Time to castration resistance is an important predictor of outcome in CRPC. PSA reduction >30\% predicts survival improvement following chemotherapy for CRPC regardless of chemotherapy applied.},
	keywords = {Advanced prostate cancer, Castrate-resistant prostate cancer, Chemotherapy, Predictors of survival, Time to castration resistance},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-79956136146\&partnerID=40\&md5=534e040ad8b7c3cd6c3172341ed1ac7f},
	author = {Bournakis, E. and Efstathiou, E. and Varkaris, A. and Wen, S. and Chrisofos, M. and Deliveliotis, C. and Alamanis, C. and Anastasiou, I. and Constantinides, C. and Bamias, A. and Dimopoulos, M.A.}
}
