@article {7881,
	title = {Treatment with granulocyte colony stimulating factor is associated with improvement in endothelial function},
	journal = {Growth Factors},
	volume = {26},
	year = {2008},
	note = {Cited By :14Export Date: 21 February 2017},
	month = {2008},
	pages = {117 - 124},
	abstract = {Primary objective: Granulocyte-colony stimulating factor (G-CSF) is used for the mobilization of bone marrow and endothelial progenitor cells, though G-CSF-induced inflammation may cause endothelial dysfunction. We examined the effects of G-CSF on endothelium, C-reactive protein (CRP), tumour necrosis factor-α (TNF-α) and anti-inflammatory cytokines namely interleukin 10 (IL-10). Research design: We studied 60 women with breast cancer, who were randomized to either subcutaneous G-CSF (5 μg/kg), o.d. for 5 days after adjuvant chemotherapy (n = 40) or placebo (n = 20). Experimental interventions: We measured flow-mediated dilatation (FMD\%) of the brachial artery by ultrasonography, CRP, TNF-α, IL-10 and the ratio TNF-α/IL-10 blood levels before, 2-h and 5-days after the G-CSF or placebo treatment. Main outcomes and results: There was a greater increase of FMD, IL-10 and reduction of TNF-α/IL-10, 2 h and 5 days after the G-CSF treatment compared to placebo. Although, CRP and TNF-α were higher, TNF-α/IL-10 was lower at the end of G-CSF treatment compared to placebo. Improvement of FMD was related to changes of IL-10 and TNF-α/IL-10. Conclusions: Treatment with G-CSF improves endothelial function in vivo, possibly by shifting the balance between the pro- and anti-inflammatory cytokines.},
	keywords = {CRP, Endothelium, Granulocyte colony stimulating factor, Interleukins},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-46249116428\&doi=10.1080\%2f08977190802090614\&partnerID=40\&md5=5ed91db95c76a4276850e4e086b58e16},
	author = {Ikonomidis, I. and Papadimitriou, C. and Vamvakou, G. and Katsichti, P. and Venetsanou, K. and Stamatelopoulos, K. and Papamichael, C. and Dimopoulos, A.-M. and Lekakis, J.}
}
